The <i>Drosophila</i> seminal proteome and its role in postcopulatory sexual selection

Wigby, Stuart ORCID: 0000-0002-2260-2948, Brown, Nora C, Allen, Sarah E, Misra, Snigdha, Sitnik, Jessica L, Sepil, Irem, Clark, Andrew G and Wolfner, Mariana F
(2020) The <i>Drosophila</i> seminal proteome and its role in postcopulatory sexual selection. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 375 (1813). 20200072-.

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Postcopulatory sexual selection (PCSS), comprised of sperm competition and cryptic female choice, has emerged as a widespread evolutionary force among polyandrous animals. There is abundant evidence that PCSS can shape the evolution of sperm. However, sperm are not the whole story: they are accompanied by seminal fluid substances that play many roles, including influencing PCSS. Foremost among seminal fluid models is <i>Drosophila melanogaster</i>, which displays ubiquitous polyandry, and exhibits intraspecific variation in a number of seminal fluid proteins (Sfps) that appear to modulate paternity share. Here, we first consolidate current information on the identities of <i>D. melanogaster</i> Sfps. Comparing between <i>D. melanogaster</i> and human seminal proteomes, we find evidence of similarities between many protein classes and individual proteins, including some <i>D. melanogaster</i> Sfp genes linked to PCSS, suggesting evolutionary conservation of broad-scale functions. We then review experimental evidence for the functions of <i>D. melanogaster</i> Sfps in PCSS and sexual conflict. We identify gaps in our current knowledge and areas for future research, including an enhanced identification of PCSS-related Sfps, their interactions with rival sperm and with females, the role of qualitative changes in Sfps and mechanisms of ejaculate tailoring. This article is part of the theme issue 'Fifty years of sperm competition'.

Item Type: Article
Uncontrolled Keywords: accessory gland, seminal plasma, seminal fluid protein, reproduction, sexual selection, sexual conflict
Depositing User: Symplectic Admin
Date Deposited: 20 Jul 2020 07:59
Last Modified: 11 Oct 2023 02:26
DOI: 10.1098/rstb.2020.0072
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