Endothelial dysfunction and carotid atherosclerosis in Malawian adults: A cross-sectional study.

Kamtchum-Tatuene, Joseph, Mwangalika Kachingwe, Gloria, Mwandumba, Henry C, Solomon, Tom ORCID: 0000-0001-7266-6547 and Benjamin, Laura A ORCID: 0000-0002-9685-1664
(2020) Endothelial dysfunction and carotid atherosclerosis in Malawian adults: A cross-sectional study. eNeurologicalSci, 20.

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Background and objective:In sub-Saharan Africa, data on prevalence, risk factors and pathobiology of carotid atherosclerosis are scarce. We aimed to investigate the relationship between biomarkers of endothelial dysfunction and carotid atherosclerosis. Methods:Carotid ultrasound was performed in 66 patients. Plasma concentration of ICAM-1, PAI-1, VEGF, and soluble thrombomodulin were measured by ELISA. A univariable logistic regression analysis was performed to study the relationship between carotid atherosclerosis, biomarkers of endothelial dysfunction, and various demographic and clinical parameters of the participants. Results:The mean age of the participants was 58.7 years (95% CI: 54.4-63.1). Carotid atherosclerosis was diagnosed in 39.4% (95% CI: 27.6-52.2). In the univariable logistic regression, the following factors were associated with carotid atherosclerosis: age > 45 years (OR = 12.0, 95% CI: 1.4-98.8, p = .02), hypertension (OR = 3.8, 95% CI: 1.2-12.1, p = .02), and high-level of soluble thrombomodulin (OR = 3.4, 95% CI: 1.2-10.0, p = .02). Conclusions:There is an association between high levels of soluble thrombomodulin and carotid atherosclerosis in Malawian adults. Further studies with a larger sample size are needed to confirm our findings in other African populations.

Item Type: Article
Uncontrolled Keywords: Endothelial dysfunction, HIV infection, Africa, Stroke, Atherosclerosis, Carotid intima-media thickness
Depositing User: Symplectic Admin
Date Deposited: 05 Aug 2020 15:25
Last Modified: 30 Mar 2021 04:10
DOI: 10.1016/j.ensci.2020.100252
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3096462