Prediction of distant metastases in patients with squamous cell carcinoma of head and neck using DWI and DCE-MRI



Chawla, Sanjeev, Kim, Sungheon G, Loevner, Laurie A, Wang, Sumei, Mohan, Suyash, Lin, Alexander and Poptani, Harish
(2020) Prediction of distant metastases in patients with squamous cell carcinoma of head and neck using DWI and DCE-MRI. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK.

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Abstract

Background The primary purpose was to evaluate the prognostic potential of diffusion imaging (DWI) and dynamic contrast enhanced magnetic resonance imaging (DCE‐MRI) in predicting distant metastases in squamous cell carcinoma of head and neck (HNSCC) patients. The secondary aim was to examine differences in DWI and DCE‐MRI‐derived parameters on the basis of human papilloma virus (HPV) status, differentiation grade, and nodal stage of HNSCC. Methods Fifty‐six patients underwent pretreatment DWI and DCE‐MRI. Patients were divided into groups who subsequently did (n = 12) or did not develop distant metastases (n = 44). Median values of apparent diffusion coefficient (ADC), volume transfer constant (Ktrans), and mean intracellular water‐lifetime (τi) and volume were computed from metastatic lymph nodes and were compared between two groups. Prognostic utility of HPV status, differentiation grading, and nodal staging was also evaluated both in isolation or in combination with MRI parameters in distinguishing patients with and without distant metastases. Additionally, MRI parameters were compared between two groups based on dichotomous HPV status, differentiation grade, and nodal stage. Results Lower but not significantly different Ktrans (0.51 ± 0.15 minute−1 vs 0.60 ± 0.05 minute−1) and not significantly different τi (0.13 ± 0.03 second vs 0.19 ± 0.02 second) were observed in patients who developed distant metastases than those who did not. Additionally, no significant differences in ADC or volume were found. τi, was the best parameter in discriminating two groups with moderate sensitivity (67%) and specificity (61.4%). Multivariate logistic regression analyses did not improve the overall prognostic performance for combination of all variables. A trend toward higher τi was observed in HPV‐positive patients than those with HPV‐negative patients. Also, a trend toward higher Ktrans was observed in poorly differentiated HNSCCs than those with moderately differentiated HNSCCs. Conclusion Pretreatment DCE‐MRI may be useful in predicting distant metastases in HNSCC.

Item Type: Article
Uncontrolled Keywords: diffusion weighted imaging, distant metastases, dynamic contrast enhanced-MRI, intracellular water life time, squamous cell carcinoma of head and neck, volume transfer constant
Depositing User: Symplectic Admin
Date Deposited: 10 Aug 2020 08:06
Last Modified: 28 May 2022 12:10
DOI: 10.1002/hed.26386
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3096676