MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators.



Aughton, Karen, Kalirai, Helen ORCID: 0000-0002-4440-2576 and Coupland, Sarah E ORCID: 0000-0002-1464-2069
(2020) MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators. International Journal of Molecular Sciences, 21 (16).

This is the latest version of this item.

[img] Text
ijms-885637 resubmission clean.docx - Accepted Version

Download (414kB)
[img] Text
ijms-21-05648-v2 (1).pdf - OA Published Version

Download (1MB) | Preview

Abstract

Uveal melanoma (UM) is a rare tumour of the eye, characterised by a high propensity to metastasise in half of all patients, most frequently to the liver. Although there are effective treatment options for the primary tumour, once metastasis has occurred prognosis is poor, with overall survival limited to months. Currently, there are no effective treatments for metastatic UM, despite the tumour having a well-defined signalling pathway to which many therapies have been directed. In an effort to develop novel treatment approaches, understanding the role of other signalling molecules, such as microRNAs, is fundamental. MicroRNAs (miRNAs) are small non-coding RNA molecules involved in posttranscriptional gene regulation, resulting in reduced target gene expression and subsequent protein translation. In UM, several dysregulated miRNAs have been proposed to play a functional role in disease progression, whereas others have been put forward as clinical biomarkers of high-risk disease following isolation from blood, plasma and exosomes. Most recently, analyses of large datasets have identified promising prognostic miRNA signatures and panels. This review navigates the plethora of aberrant miRNAs disclosed so far in UM, and maps these to signalling pathways, which could be targeted in future therapies for the disseminated disease.

Item Type: Article
Uncontrolled Keywords: uveal melanoma (UM), miRNA, biomarkers
Depositing User: Symplectic Admin
Date Deposited: 26 Aug 2020 09:47
Last Modified: 09 Sep 2021 13:27
DOI: 10.3390/ijms21165648
Open Access URL: https://doi.org/10.3390/ijms21165648
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3098922

Available Versions of this Item