Myocardial protection in cardiac surgery: how limited are the options? A comprehensive literature review



Whittaker, Abigail, Aboughdir, Maryam, Mahbub, Samiha, Ahmed, Amna and Harky, Amer ORCID: 0000-0001-5507-5841
(2020) Myocardial protection in cardiac surgery: how limited are the options? A comprehensive literature review. Perfusion (United Kingdom).

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Abstract

For patients undergoing cardiopulmonary bypass, myocardial protection is a key for successful recovery and improved outcomes following cardiac surgery that requires cardiac arrest. Different solutions, components and modes of delivery have evolved over the last few decades to optimise myocardial protection. These include cold and warm and blood and crystalloid solution through antegrade, retrograde or combined cardioplegia delivery approach. However, each method has its own advantages and disadvantages, posing a challenge to establish a gold-standard cardioplegic solution with an optimised mode of delivery for enhanced myocardial protection during cardiac surgery. The aim of this review is to provide a brief history of the development of cardioplegia, explain the electrophysiological concepts behind myocardial protection in cardioplegia, analyse the current literature and summarise existing evidence that warrants the use of varying cardioplegic techniques. We provide a comprehensive and comparative overview of the effectiveness of each technique in achieving optimal cardioprotection and propose novel techniques for optimising myocardial protection in the future.

Item Type: Article
Uncontrolled Keywords: myocardial protection, cardioplegia, cardiac arrest, cold blood, open heart
Depositing User: Symplectic Admin
Date Deposited: 28 Aug 2020 09:28
Last Modified: 05 Nov 2020 19:41
DOI: 10.1177/0267659120942656
Related URLs:
URI: http://livrepository.liverpool.ac.uk/id/eprint/3099107