Alkanhal, Hatham
(2020)
Evaluating the role of Diffusion Tensor Imaging and Dynamic Susceptibility Contrast perfusion imaging in the diagnosis of non-enhancing brain tumours
PhD thesis, University of Liverpool.
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Abstract
Background: Diagnosis of non-enhancing brain tumours is challenging, as a substantial degree of overlap (over 45%) has been reported between low-grade and high-grade tumours using conventional Magnetic resonance imaging (MRI) methods. Whilst some studies using Diffusion Tensor Imaging (DTI) and perfusion weighted imaging using Dynamic susceptibility Contrast (DSC) MRI have suggested that these aid in the differential diagnosis of tumours, no further studies have been performed in non-enhancing tumours. Objectives: The first purpose of this thesis was to quantitatively analyse pre-existing MRI data from non-enhancing brain tumour patients to evaluate whether DTI and DSC imaging can aid in the differentiation of GII from GIII tumours and whether these imaging methods can accurately identify glioma subtypes, including astrocytomas and oligodendrogliomas. The second purpose of this thesis, was to evaluate whether conventional MRI methods can predict progression of a low-grade tumour to a highgrade tumour using longitudinal MRI data. Methods: A total number of 80 patients with non-enhancing gliomas, 49 patients with GII gliomas (27 astrocytoma, 22 oligodendroglioma), 23 patients with GIII gliomas (20 anaplastic ... (continues)
| Item Type: | Thesis (PhD) |
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| Divisions: | Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > School of Medicine |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Jan 2021 14:05 |
| Last Modified: | 29 Oct 2024 16:56 |
| DOI: | 10.17638/03099598 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3099598 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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