Degenhardt, Karoline, Wagner, Jessica, Skodras, Angelos, Candlish, Michael, Koppelmann, Anna Julia, Wild, Katleen, Maxwell, Rusheka, Rotermund, Carola, von Zweydorf, Felix, Gloeckner, Christian Johannes et al (show 10 more authors)
(2020)
Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.
Proceedings of the National Academy of Sciences of the United States of America, 117 (38).
pp. 23925-23931.
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Abstract
Medin is the most common amyloid known in humans, as it can be found in blood vessels of the upper body in virtually everybody over 50 years of age. However, it remains unknown whether deposition of Medin plays a causal role in age-related vascular dysfunction. We now report that aggregates of Medin also develop in the aorta and brain vasculature of wild-type mice in an age-dependent manner. Strikingly, genetic deficiency of the Medin precursor protein, MFG-E8, eliminates not only vascular aggregates but also prevents age-associated decline of cerebrovascular function in mice. Given the prevalence of Medin aggregates in the general population and its role in vascular dysfunction with aging, targeting Medin may become a novel approach to sustain healthy aging.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Medin, MFG-E8, cerebrovascular dysfunction, aging, amyloid |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Sep 2020 09:50 |
| Last Modified: | 18 Jan 2023 23:33 |
| DOI: | 10.1073/pnas.2011133117 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3100797 |
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