Targeting DNA Repair Pathways in Hematological Malignancies



Alhmoud, Jehad F, Mustafa, Ayman G and Malki, Mohammed Imad
(2020) Targeting DNA Repair Pathways in Hematological Malignancies. International Journal of Molecular Sciences, 21 (19). 7365 - 7365.

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Abstract

<jats:p>DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple genomic changes that ultimately may result in mutation, tumor growth, and/or cell apoptosis. Furthermore, impaired repair mechanisms can also lead to genomic instability, which can initiate tumorigenesis and development of hematological malignancy. This review discusses recent findings and highlights the importance of DNA repair components and the impact of their aberrations on hematological malignancies.</jats:p>

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 08 Oct 2020 08:15
Last Modified: 28 Mar 2021 03:11
DOI: 10.3390/ijms21197365
Open Access URL: https://www.mdpi.com/1422-0067/21/19/7365
URI: https://livrepository.liverpool.ac.uk/id/eprint/3103859