A systematic review finds core outcome set uptake varies widely across different areas of health.



Hughes, Karen L ORCID: 0000-0002-8517-8996, Clarke, Mike and Williamson, Paula R ORCID: 0000-0001-9802-6636
(2020) A systematic review finds core outcome set uptake varies widely across different areas of health. Journal of Clinical Epidemiology.

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Abstract

The aim of our review was to bring together studies that had assessed the uptake of core outcome sets (COS) to explore the level of uptake across different COS and areas of health. We examined the citations of 337 COS reports to identify studies that had assessed the uptake of a particular COS in randomised controlled trials (RCTs) or systematic reviews (SRs). We identified 24 studies that had assessed uptake in RCTs and two studies that has assessed uptake in SRs. The studies covered a total of 17/337 (5%) COS. Uptake rates reported for RCTs varied from 0% of RCTs (gout) to 82% RCTs (rheumatoid arthritis) measuring the full COS. Studies that assessed uptake of individual core outcomes showed wide variation in uptake between the outcomes. Suggested barriers to uptake included lack of validated measures, lack of patient and other key stakeholder involvement in COS development and lack of awareness of the COS. Few studies have been undertaken to assess the uptake of COS in RCTs and SRs. Further studies are needed to assess whether COS have been implemented across a wider range of disease categories and to explore the barriers and facilitators to COS uptake.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 09 Oct 2020 08:32
Last Modified: 29 Oct 2021 11:46
DOI: 10.1016/j.jclinepi.2020.09.029
URI: https://livrepository.liverpool.ac.uk/id/eprint/3103922