Genetic architecture of subcortical brain structures in 38,851 individuals

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Satizabal, Claudia L, Adams, Hieab HH, Hibar, Derrek P, White, Charles C, Knol, Maria J, Stein, Jason L, Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V et al (show 279 more authors) , Smith, Albert V, Bis, Joshua C, Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J, Yang, Jingyun, Yanek, Lisa R, Lee, Tom V, Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D, Desrivieres, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentera, Miguel E, Kim, Sungeun, Hoehn, David, Armstrong, Nicola J, Chen, Qiang, Holmes, Avram J, den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santianez, Roberto, Kraemer, Bernd, Haberg, Asta K, Jones, Hannah J, Pike, G Bruce, Stein, Dan J, Stevens, Allison, Bralten, Janita, Vernooij, Meike W, Harris, Tamara B, Filippi, Irina, Witte, A Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H, Becker, James T, Nhat, Trung Doan, Hagenaars, Saskia P, Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M, Ames, David, Goldman, Aaron L, Lee, Phil H, Boomsma, Dorret I, Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M, Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M, Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E, Shin, Jean, Ipser, Jonathan C, Vinke, Louis N, Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K, Aribisala, Benjamin S, Schmidt, Helena, Strike, Lachlan T, Cheng, Ching-Yu, Risacher, Shannon L, Puetz, Benno, Fleischman, Debra A, Assareh, Amelia A, Mattay, Venkata S, Buckner, Randy L, Mecocci, Patrizia, Dale, Anders M, Cichon, Sven, Boks, Marco P, Matarin, Mar, Penninx, Brenda WJH, Calhoun, Vince D, Chakravarty, M Mallar, Marquand, Andre F, Macare, Christine, Masouleh, Shahrzad Kharabian, Oosterlaan, Jaap, Amouyel, Philippe, Hegenscheid, Katrin, Rotter, Jerome I, Schork, Andrew J, Liewald, David CM, de, Zubicaray Greig I, Wong, Tien Yin, Shen, Li, Saemann, Philipp G, Brodaty, Henry, Roffman, Joshua L, de Geus, Eco JC, Tsolaki, Magda, Erk, Susanne, van Eijk, Kristel R, Cavalleri, Gianpiero L, van der Wee, Nic JA, McIntosh, Andrew M, Gollub, Randy L, Bulayeva, Kazima B, Bernard, Manon, Richards, Jennifer S, Himali, Jayandra J, Loeffler, Markus, Rommelse, Nanda, Hoffmann, Wolfgang, Westlye, Lars T, Hernandez, Maria C Valdes, Hansell, Narelle K, van Erp, Theo GM, Wolf, Christiane, Kwok, John BJ, Vellas, Bruno, Heinz, Andreas, Loohuis, Loes M Olde, Delanty, Norman, Ho, Beng-Choon, Ching, Christopher RK, Shumskaya, Elena, Singh, Baljeet, Hofman, Albert, van der Meer, Dennis, Homuth, Georg, Psaty, Bruce M, Bastin, Mark E, Montgomery, Grant W, Foroud, Tatiana M, Reppermund, Simone, Hottenga, Jouke-Jan, Simmons, Andrew, Meyer-Lindenberg, Andreas, Cahn, Wiepke, Whelan, Christopher D, van Donkelaar, Marjolein MJ, Yang, Qiong, Hosten, Norbert, Green, Robert C, Thalamuthu, Anbupalam, Mohnke, Sebastian, Pol, Hilleke E Hulshoff, Lin, Honghuang, Jack, Clifford R Jr, Schofield, Peter R, Muehleisen, Thomas W, Maillard, Pauline, Potkin, Steven G, Wen, Wei, Fletcher, Evan, Toga, Arthur W, Gruber, Oliver, Huentelman, Matthew, Smith, George Davey, Launer, Lenore J, Nyberg, Lars, Jonsson, Erik G, Crespo-Facorro, Benedicto, Koen, Nastassja, Greve, Douglas N, Uitterlinden, Andre G, Weinberger, Daniel R, Steen, Vidar M, Fedko, Iryna O, Groenewold, Nynke A, Niessen, Wiro J, Toro, Roberto, Tzourio, Christophe, Longstreth, William T Jr, Ikram, M Kamran, Smoller, Jordan W, van Tol, Marie-Jose, Sussmann, Jessika E, Paus, Tomas, Lemaitre, Herve, Schroeter, Matthias L, Mazoyer, Bernard, Andreassen, Ole A, Holsboer, Florian, Depondt, Chantal, Veltman, Dick J, Turner, Jessica A, Pausova, Zdenka, Schumann, Gunter, van Rooij, Daan, Djurovic, Srdjan, Deary, Ian J, McMahon, Katie L, Mueller-Myhsok, Bertram ORCID: 0000-0002-0719-101X, Brouwer, Rachel M, Soininen, Hilkka, Pandolfo, Massimo, Wassink, Thomas H, Cheung, Joshua W, Wolfers, Thomas, Martinot, Jean-Luc, Zwiers, Marcel P, Nauck, Matthias, Melle, Ingrid, Martin, Nicholas G, Kanai, Ryota, Westman, Eric, Kahn, Rene S, Sisodiya, Sanjay M, White, Tonya, Saremi, Arvin, van Bokhoven, Hans, Brunner, Han G, Voelzke, Henry, Wright, Margaret J, van't Ent, Dennis, Noethen, Markus M, Ophoff, Roel A, Buitelaar, Jan K, Fernandez, Guilln, Sachdev, Perminder S, Rietschel, Marcella, van Haren, Neeltje EM, Fisher, Simon E, Beiser, Alexa S, Francks, Clyde, Saykin, Andrew J, Mather, Karen A, Romanczuk-Seiferth, Nina, Hartman, Catharina A, DeStefano, Anita L, Heslenfeld, Dirk J, Weiner, Michael W, Walter, Henrik, Hoekstra, Pieter J, Nyquist, Paul A, Franke, Barbara, Bennett, David A, Grabe, Hans J, Johnson, Andrew D, Chen, Christopher, van Duijn, Cornelia M, Lopez, Oscar L, Fornage, Myriam, Wardlaw, Joanna M, Schmidt, Reinhold, DeCarli, Charles, De Jager, Philip L, Villringer, Arno, Debette, Stephanie, Gudnason, Vilmundur, Medland, Sarah E, Shulman, Joshua M, Thompson, Paul M, Seshadri, Sudha and Ikram, M Arfan (2019) Genetic architecture of subcortical brain structures in 38,851 individuals. NATURE GENETICS, 51 (11). 1624-+.

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Abstract

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

Item Type:	Article
Uncontrolled Keywords:	Brain, Animals, Humans, Drosophila melanogaster, Magnetic Resonance Imaging, Organ Size, Cohort Studies, Adult, Aged, Middle Aged, Genetic Variation, Genome-Wide Association Study, Neurodevelopmental Disorders
Depositing User:	Symplectic Admin
Date Deposited:	12 Oct 2020 08:02
Last Modified:	18 Jan 2023 23:29
DOI:	10.1038/s41588-019-0511-y
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3104005