Safety perspectives on presently considered drugs for the treatment of COVID‐19



Penman, Sophie L ORCID: 0000-0001-5326-1675, Kiy, Robyn T ORCID: 0000-0001-7960-7283, Jensen, Rebecca L ORCID: 0000-0003-1134-2869, Beoku‐Betts, Christopher, Alfirevic, Ana ORCID: 0000-0002-2801-9817, Back, David, Khoo, Saye H, Owen, Andrew ORCID: 0000-0002-9819-7651, Pirmohamed, Munir ORCID: 0000-0002-7534-7266, Park, B Kevin ORCID: 0000-0001-8384-824X
et al (show 3 more authors) (2020) Safety perspectives on presently considered drugs for the treatment of COVID‐19. British Journal of Pharmacology.

This is the latest version of this item.

[img] Text
Safety perspectives on presently considered drugs for the treatment of COVID-19.pdf - OA Published Version

Download (5MB) | Preview

Abstract

Intense efforts are underway to evaluate potential therapeutic agents for the treatment of COVID‐19. In order to respond quickly to the crisis, the repurposing of existing drugs is the primary pharmacological strategy. Despite the urgent clinical need for these therapies, it is imperative to consider potential safety issues. This is important due to the harm–benefit ratios that may be encountered when treating COVID‐19, which can depend on the stage of the disease, when therapy is administered and underlying clinical factors in individual patients. Treatments are currently being trialled for a range of scenarios from prophylaxis (where benefit must greatly exceed risk) to severe life‐threatening disease (where a degree of potential risk may be tolerated if it is exceeded by the potential benefit). In this perspective, we have reviewed some of the most widely researched repurposed agents in order to identify potential safety considerations using existing information in the context of COVID‐19.

Item Type: Article
Uncontrolled Keywords: COVID-19, drug repurposing, drug safety, toxicology
Depositing User: Symplectic Admin
Date Deposited: 12 Oct 2020 15:04
Last Modified: 18 Dec 2021 12:32
DOI: 10.1111/bph.15204
Open Access URL: https://bpspubs.onlinelibrary.wiley.com/doi/epdf/1...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3104050

Available Versions of this Item