Atrial fibrillation and the risk of 30-day incident thromboembolic events and mortality in adults ≥50 years with COVID-19



Harrison, Stephanie ORCID: 0000-0002-8846-0946, Fazio-Eynullayeva, Elnara, Lane, Deirdre ORCID: 0000-0002-5604-9378, Underhill, Paula and Lip, Gregory ORCID: 0000-0002-7566-1626
(2020) Atrial fibrillation and the risk of 30-day incident thromboembolic events and mortality in adults ≥50 years with COVID-19. Journal of Arrhythmia, 37 (1). pp. 231-237.

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Abstract

<h4>Background</h4>There are limited data on the outcomes of adults with coronavirus disease 2019 (COVID-19) and atrial fibrillation (AF). The objectives were to (i) examine associations between AF, 30-day thromboembolic events and mortality in adults with COVID-19 and (ii) examine associations between COVID-19, 30-day thromboembolic events and mortality in adults with AF.<h4>Methods</h4>A study was conducted using a global federated health research network. Adults aged ≥50 years who presented to 41 participating healthcare organizations between 20 January 2020 and 1 September 2020 with COVID-19 were included.<h4>Results</h4>For the first objective, 6589 adults with COVID-19 and AF were propensity score matched for age, gender, race, and comorbidities to 6589 adults with COVID-19 without AF. The survival probability was significantly lower in adults with COVID-19 and AF compared to matched adults without AF (82.7% compared to 88.3%, Log-Rank test <i>P</i> < .0001; Risk Ratio (95% confidence interval) 1.61 (1.46, 1.78)) and risk of thromboembolic events was higher in patients with AF (9.9% vs 7.0%, Log-Rank test <i>P</i> < .0001; Risk Ratio (95% confidence interval) 1.41 (1.26, 1.59)). For the second objective, 2454 adults with AF and COVID-19 were propensity score matched to 2454 adults with AF without COVID-19. The survival probability was significantly lower for adults with AF and COVID-19 compared to adults with AF without COVID-19, but there was no significant difference in risk of thromboembolic events.<h4>Conclusions</h4>AF could be an important risk factor for short-term mortality with COVID-19, and COVID-19 may increase risk of short-term mortality amongst adults with AF.

Item Type: Article
Uncontrolled Keywords: atrial fibrillation, coronavirus-2019, COVID-19, mortality, thromboembolic events
Depositing User: Symplectic Admin
Date Deposited: 04 Nov 2020 10:55
Last Modified: 18 Jan 2023 23:23
DOI: 10.1002/joa3.12458
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3105947