A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters

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Kostaki, Evangelia Georgia, Gova, Maria, Adamis, Georgios, Xylomenos, Georgios, Chini, Maria, Mangafas, Nikos, Lazanas, Marios, Metallidis, Simeon, Tsachouridou, Olga, Papastamopoulos, Vasileios et al (show 26 more authors) , Chatzidimitriou, Dimitrios, Kakalou, Eleni, Antoniadou, Anastasia, Papadopoulos, Antonios, Psichogiou, Mina, Basoulis, Dimitrios, Pilalas, Dimitrios, Papageorgiou, Ifigeneia, Paraskeva, Dimitra, Chrysos, Georgios, Paparizos, Vasileios, Kourkounti, Sofia, Sambatakou, Helen, Bolanos, Vasileios, Sipsas, Nikolaos V, Lada, Malvina, Barbounakis, Emmanouil, Kantzilaki, Evrikleia, Panagopoulos, Periklis, Petrakis, Vasilis, Drimis, Stelios, Gogos, Charalambos, Hatzakis, Angelos, Beloukas, Apostolos ORCID: 0000-0001-5639-0528, Skoura, Lemonia and Paraskevis, Dimitrios (2020) A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters. VIRUSES-BASEL, 12 (10). E1183-.

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Abstract

Our aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.8%) sequences of subtype A1 and B, respectively. Identification of MTCs was based on phylogenetic analysis. The analyses identified 38 MTCs including 2-1518 subtype A1 sequences and 168 MTCs in the range of 2-218 subtype B sequences. The proportion of sequences within MTCs was 93.8% (1642/1751) and 77.0% (1982/2575) for subtype A1 and B, respectively. Transmissions within MTCs for subtype A1 were associated with risk group (Men having Sex with Men vs. heterosexuals, OR = 5.34, <i>p</i> < 0.001) and Greek origin (Greek vs. non-Greek origin, OR = 6.05, <i>p</i> < 0.001) and for subtype B, they were associated with Greek origin (Greek vs. non-Greek origin, OR = 1.57, <i>p</i> = 0.019), younger age (OR = 0.96, <i>p</i> < 0.001), and more recent sampling (time period: 2011-2015 vs. 1999-2005, OR = 3.83, <i>p</i> < 0.001). Our findings about the patterns of across and within country dispersal as well as the parameters associated with transmission within MTCs provide a framework for the application of the study of molecular clusters for HIV prevention.

Item Type:	Article
Uncontrolled Keywords:	human immunodeficiency virus (HIV), molecular epidemiology, phylogenetic analysis, phylogeographic analysis, local transmission, dispersal patterns, transmission clusters, Greece
Depositing User:	Symplectic Admin
Date Deposited:	04 Nov 2020 15:38
Last Modified:	13 Feb 2024 17:07
DOI:	10.3390/v12101183
Open Access URL:	https://doi.org/10.3390/v12101183
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3106047