Lupus IgG deposition causes arthritis but inhibits bone destruction through competitive occupation of FcγRI and reduced RANKL signalling

Qiao, Wei, Ding, Huimin, Zuo, Yuyue, Jiang, Lijuan, Zhou, Jiayuan, Han, Xiaoxiao, Yu, Likai, Du, Rong, Hedrich, Christian ORCID: 0000-0002-1295-6179 and Deng, Guo-Min (2020) Lupus IgG deposition causes arthritis but inhibits bone destruction through competitive occupation of FcγRI and reduced RANKL signalling. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 9 (9). e1174-.

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Official URL: http://dx.doi.org/10.1002/cti2.1174

Abstract

<h4>Objectives</h4>Bone destruction is a remarkable feature of inflammatory arthritis. It remains unknown why arthritis associated with the systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE) does not result in erosion and destruction. We aimed to determine the role of autoantibody in the pathogenesis of non-erosive arthritis in SLE.<h4>Methods</h4>We analysed medical record of SLE patients, investigated whether autoantibody induces arthritis lacking bone destruction in animal models and determined whether SLE autoantibody inhibits osteoclastogenesis induced by RANKL <i>in vitro</i> experiments.<h4>Results</h4>We found that arthritis lacking bone erosions is common in SLE patients and lupus-prone mice. Intraarticular injection of lupus serum or IgG induces immune complex deposition and arthritis, but does not result in bone destruction. Deposition of IgG, monocytes/macrophages and TNF-α is all required for the development of arthritis. Lupus serum or IgG inhibits RANKL-induced differentiation of monocytes into osteoclast in a dose-dependent manner. FcγR acts as co-receptors for RANKL and is involved in osteoclastogenesis. Deficiency of FcγRII or FcγRIII does not affect osteoclastogenesis in the presence of SLE IgG. However, lupus IgG competes for FcγRI binding with RANKL, thereby reducing osteoclastogenesis.<h4>Conclusion</h4>Observations from this study demonstrate that IgG from SLE patients can induce arthritis and inhibits RANKL-induced osteoclastogenesis through competitive occupation of FcγRI on monocytes/macrophages. This study improves the understanding of the pathophysiology of SLE-associated arthritis and offers a protective mechanism (FcγRI inhibition) that may be targeted in other forms of autoimmune/inflammatory arthritis, such as RA, to prevent or limit bone erosion and inflammatory bone loss.

Item Type:	Article
Uncontrolled Keywords:	arthritis, bone destruction, Fc gamma receptor, IgG, osteoclastogenesis, systemic lupus erythematosus
Depositing User:	Symplectic Admin
Date Deposited:	05 Nov 2020 10:15
Last Modified:	14 Oct 2023 18:55
DOI:	10.1002/cti2.1174
Open Access URL:	https://doi.org/10.1002/cti2.1174
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3106085