Tracking the establishment of local endemic populations of an emergent enteric pathogen.

Holt, Kathryn E ORCID: 0000-0003-3949-2471, Thieu Nga, Tran Vu, Thanh, Duy Pham, Vinh, Ha, Kim, Dong Wook ORCID: 0000-0001-5351-7597, Vu Tra, My Phan, Campbell, James I, Hoang, Nguyen Van Minh, Vinh, Nguyen Thanh, Minh, Pham Van
et al (show 20 more authors) (2013) Tracking the establishment of local endemic populations of an emergent enteric pathogen. Proceedings of the National Academy of Sciences of the United States of America, 110 (43). pp. 17522-17527.

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Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.

Item Type: Article
Uncontrolled Keywords: Chromosomes, Bacterial, Humans, Shigella sonnei, Dysentery, Bacillary, Fluoroquinolones, Ciprofloxacin, Anti-Bacterial Agents, Sequence Analysis, DNA, Genomics, Endemic Diseases, Evolution, Molecular, Phylogeny, Genome, Bacterial, Geography, Molecular Sequence Data, Child, Child, Preschool, Infant, Vietnam, Genetic Variation, Mutation Rate, Gatifloxacin
Depositing User: Symplectic Admin
Date Deposited: 18 Nov 2020 09:56
Last Modified: 18 Mar 2024 01:01
DOI: 10.1073/pnas.1308632110
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