Long-term bisphosphonate treatment coupled with ovariectomy in mice provokes deleterious effects on femoral neck fracture pattern and modifies tibial shape

Monzem, S, Ballester, RY, Javaheri, B, Poulet, B, Sonego, DA, Pitsillides, AA and Souza, RL (2020) Long-term bisphosphonate treatment coupled with ovariectomy in mice provokes deleterious effects on femoral neck fracture pattern and modifies tibial shape. BONE & JOINT OPEN, 1 (9). pp. 512-519.

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Official URL: http://dx.doi.org/10.1302/2633-1462.19.bjo-2020-01...

Abstract

<h4>Aims</h4>The processes linking long-term bisphosphonate treatment to atypical fracture remain elusive. To establish a means of exploring this link, we have examined how long-term bisphosphonate treatment with prior ovariectomy modifies femur fracture behaviour and tibia mass and shape in murine bones.<h4>Methods</h4>Three groups (seven per group) of 12-week-old mice were: 1) ovariectomized and 20 weeks thereafter treated weekly for 24 weeks with 100 μm/kg subcutaneous ibandronate (OVX+IBN); 2) ovariectomized (OVX); or 3) sham-operated (SHAM). Quantitative fracture analysis generated biomechanical properties for the femoral neck. Tibiae were microCT scanned and trabecular (proximal metaphysis) and cortical parameters along almost its whole length measured.<h4>Results</h4>Fracture analyses revealed that OVX+IBN significantly reduced yield displacement (vs SHAM/OVX) and resilience, and increased stiffness (vs SHAM). OVX+IBN elevated tibial trabecular parameters and also increased cortical cross-sectional area and second moment of area around minor axis, and diminished ellipticity proximally.<h4>Conclusion</h4>These data indicate that combined ovariectomy and bisphosphonate generates cortical changes linked with greater bone brittleness and modified fracture characteristics, which may provide a basis in mice for interrogating the mechanisms and genetics of atypical fracture aetiology.Cite this article: <i>Bone Joint Open</i> 2020;1-9:512-519.

Item Type:	Article
Uncontrolled Keywords:	bone quality, bone strength, Ibandronate, Biomechanical properties, bone geometry
Depositing User:	Symplectic Admin
Date Deposited:	10 Dec 2020 08:24
Last Modified:	18 Jan 2023 23:19
DOI:	10.1302/2633-1462.19.BJO-2020-0117-R1
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3109769