Connecting the dots: combined control of endocytic recycling and degradation

MacDonald, Ewan, Savage, Bryan and Zech, Tobias ORCID: 0000-0001-8394-088X (2020) Connecting the dots: combined control of endocytic recycling and degradation. BIOCHEMICAL SOCIETY TRANSACTIONS, 48 (6). pp. 2377-2386.

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Official URL: http://dx.doi.org/10.1042/bst20180255

Abstract

Endocytosis is an essential process where proteins and lipids are internalised from the plasma membrane in membrane-bound carriers, such as clathrin-coated vesicles. Once internalised into the cell these vesicles fuse with the endocytic network where their contents are sorted towards degradation in the lysosome or recycling to their origin. Initially, it was thought that cargo recycling is a passive process, but in recent years the identification and characterisation of specialised recycling complexes has established a hitherto unthought-of level of complexity that actively opposes degradation. This review will summarise recent developments regarding the composition and regulation of the recycling machineries and their relationship with the degradative pathways of the endosome.

Item Type:	Article
Uncontrolled Keywords:	Cell Membrane, Organelles, Endosomes, Lysosomes, Clathrin-Coated Vesicles, Golgi Apparatus, Animals, Humans, Clathrin, Ubiquitin, Ligands, Signal Transduction, Endocytosis, Pinocytosis, Amino Acid Motifs, Biological Transport, Protein Transport, Phosphorylation, Models, Biological, Actin Cytoskeleton
Depositing User:	Symplectic Admin
Date Deposited:	12 Jan 2021 11:31
Last Modified:	18 Jan 2023 23:05
DOI:	10.1042/BST20180255
Open Access URL:	https://doi.org/10.1042/BST20180255
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3110799