Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.

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Drake, Thomas, Docherty, Annemarie, Harrison, Ewen ORCID: 0000-0002-5018-3066, Quint, Jennifer, Adamali, Huzaifa ORCID: 0000-0002-8230-175X, Adamali, Huzaifa ORCID: 0000-0003-0149-4869, Agnew, Sarah, Babu, Suresh, Barber, Christopher, Barratt, Shaney et al (show 63 more authors) , Bendstrup, Elisabeth ORCID: 0000-0002-4238-6963, Bendstrup, Elisabeth ORCID: 0000-0003-3067-7349, Bianchi, Stephen, Villegas, Diego Castillo, Chaudhuri, Nazia ORCID: 0000-0003-3325-6996, Chua, Felix ORCID: 0000-0001-7845-0173, Coker, Robina, Chang, William, Crawshaw, Anjali, Crowley, Louise, Dosanjh, Davinder, Fiddler, Christine, Forrest, Ian, George, Peter, Gibbons, Michael ORCID: 0000-0001-7099-1872, Groom, Katherine, Haney, Sarah, Hart, Simon, Heiden, Emily, Henry, Michael, Ho, Ling-Pei ORCID: 0000-0001-8319-301X, Hoyles, Rachel, Hutchinson, John, Hurley, Killian, Jones, Mark, Jones, Steve, Kokosi, Maria, Kreuter, Michael, MacKay, Laura, Mahendran, Siva, Margaritopoulos, George, Molina-Molina, Maria, Molyneaux, Philip ORCID: 0000-0003-1301-8800, O’Brien, Aiden, O’Reilly, Katherine, Packham, Alice, Parfrey, Helen, Poletti, Venerino, Porter, Joanna ORCID: 0000-0002-7307-169X, Renzoni, Elisabetta, Rivera-Ortega, Pilar, Russell, Anne-Marie, Saini, Gauri, Spencer, Lisa, Stella, Giulia, Stone, Helen, Sturney, Sharon, Thickett, David, Thillai, Muhunthan, Wallis, Tim, Ward, Katie, Wells, Athol, West, Alex, Wickremasinghe, Melissa, Woodhead, Felix, Hearson, Glenn ORCID: 0000-0002-5815-3996, Howard, Lucy ORCID: 0000-0003-0756-3415, Baillie, Kenneth, Openshaw, Peter JM, Semple, Malcolm ORCID: 0000-0001-9700-0418, Stewart, Iain, Jenkins, Gisli and ISARIC4C Investigators, ORCID: 0000-0002-7929-2119 (2020) Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study. medrxiv. 2020.07.15.20152967-.

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Abstract

<h4>Rationale</h4> The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. <h4>Objectives</h4> To assess outcomes following COVID-19 in patients with ILD versus those without in a contemporaneous age, sex and comorbidity matched population. <h4>Methods</h4> An international multicentre audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. <h4>Measurements and Main Results</h4> Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and comorbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of <80% had an increased risk of death versus patients with FVC ≥80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 1.98, 1.13−3.46). <h4>Conclusions</h4> Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD.

Item Type:	Article
Uncontrolled Keywords:	ISARIC4C Investigators
Depositing User:	Symplectic Admin
Date Deposited:	08 Jan 2021 15:24
Last Modified:	14 Mar 2024 20:33
DOI:	10.1101/2020.07.15.20152967
Open Access URL:	https://doi.org/10.1101/2020.07.15.20152967
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3112071