DESIGNING A HUMAN CELL PERFUSION BIOREACTOR SYSTEMS UTILISING BIOMATERIALS TO ENRICH STEM CELL NICHES FOR THE RED BLOOD CELLS PRODUCTION



Bin Rahmat Sam, Mohd Fuad
(2021) DESIGNING A HUMAN CELL PERFUSION BIOREACTOR SYSTEMS UTILISING BIOMATERIALS TO ENRICH STEM CELL NICHES FOR THE RED BLOOD CELLS PRODUCTION. Doctor of Philosophy thesis, University of Liverpool.

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Abstract

The short shelf life along with the constant threat or an actual shortage of red blood cells (RBCs) places an ever-present constant stress on the healthcare providers to maintain and then increase blood donations to meet blood product demands. Blood transfusion services are already at a critical point trying to meet this constant and increasing demand. Made worse by the low numbers of people actually donating blood (7% U.K., 13% Taiwan). To add to this time dependant critical balance for blood supply and demand, the increase in outbreaks in the transmission of blood carried infectious diseases have caused safety issues. For many years, a number of researchers around the world have been attempting to use progenitor cells from various sources as the origin to produce RBCs; these include bone marrow, umbilical cord blood and mobilised peripheral blood. In order to avoid any potential negative side effects associated with stem cell-mobilizing agents, the research in this thesis utilised steady state peripheral blood as the potential source for in vitro RBC production.

Item Type: Thesis (Doctor of Philosophy)
Divisions: Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 03 Sep 2021 10:43
Last Modified: 23 Jul 2022 22:20
DOI: 10.17638/03114297
Supervisors:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3114297