Mohammad, Ishaque 
ORCID: 0000-0001-7913-8026
(2021)
Molecular characterisation of interaction between nurse-like cells and chronic lymphocytic leukaemia cells.
PhD thesis, University of Liverpool.
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Abstract
Chronic Lymphocytic Leukaemia (CLL) is a proliferative B cell malignancy characterised by an accumulation of mature B cells in the peripheral blood, lymph nodes and bone marrow. The disease is heterogenous in both clinical presentation and response to treatment. Despite the well-established immunochemotherapy and recently introduced molecularly targeted therapies such as ibrutinib and venetoclax, CLL is still incurable. One possible cause of relapse in patients is the involvement of the tissue microenvironment which supports CLL-cell survival and confers drug resistance. Nurse like cells (NLCs) are a major component of the CLL microenvironment. However, the exact molecular mechanisms mediating interactions between CLL cells and NLCs are still not fully understood. The aim of this study was to investigate how NLCs and CLL cells influence each other at the level of gene expression and to uncover molecules and pathways that are responsible for prolonging survival and conferring drug resistance of CLL cells. I therefore independently characterised the development of NLCs using fresh peripheral blood samples from CLL patients and applied a co-culture system where primary CLL cells were cultured with NLCs. I showed ... (continues)
| Item Type: | Thesis (PhD) |
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| Divisions: | Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Jun 2021 13:56 |
| Last Modified: | 30 Sep 2024 02:15 |
| DOI: | 10.17638/03114800 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3114800 |
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