Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection


Hobson, James ORCID: 0000-0003-2551-1774, Savage, Alison, Dwyer, Andrew, Unsworth, Catherine, Arshad, Usman, Pertinez, Henry, box, helen, Tatham, Lee, Rajoli, Rajith ORCID: 0000-0002-6015-5712, Neary, Megan ORCID: 0000-0002-4960-2139 et al (show 8 more authors) (2021) Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. Unknown.

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Abstract

The spread of SARS-CoV-2 across the world requires the formation of a range of interventions that include immunomodulatory or antiviral therapeutics and repurposing of existing drug compounds is an important strategy to rapidly identify possible options. Niclosamide is a cheap and generic drug compound with a proven in vitro ability to inhibit viral replication of SARS-CoV-2; this drug also has known poor oral bioavailability due to very low water solubility. Here, we demonstrate the nanoparticle formulation of niclosamide using a new, cheap and scalable process to enable long-acting injectable administration and show extended circulating drug exposure in vivo over 28 days using a rodent model after depot injection.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 29 Jan 2021 11:33
Last Modified: 18 Jan 2023 23:01
DOI: 10.26434/chemrxiv.13587035.v1
Open Access URL: https://doi.org/10.26434/chemrxiv.13587035.v1
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3114960
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