Obesity and atrial fibrillation: making inroads through fat

Javed, Saad, Gupta, Dhiraj and Lip, Gregory YH ORCID: 0000-0002-7566-1626 (2021) Obesity and atrial fibrillation: making inroads through fat. EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 7 (1). pp. 59-67.

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Abstract

The global prevalence of obesity has reached epidemic proportions, paralleled by a rise in cases of atrial fibrillation (AF). Data from epidemiological cohorts support the role of obesity as an independent risk factor for AF. Increasing evidence indicates that obesity may contribute to the AF substrate through a number of pathways including by altering epicardial adipose tissue biology, inflammatory pathways, structural cardiac remodelling, and inducing atrial fibrosis. Due to changes in pharmacokinetics and pharmacodynamics, specific therapeutic considerations are required to guide management of patients with AF including anticoagulation and rhythm control. Also, weight loss in patients with AF has been associated with reduced progression from paroxysmal to persistent AF and indeed regression from persistent to proximal AF. However, the role of dietary intervention in AF control remains to be fully elucidated and hard prospective outcome data to support weight loss are required in AF to determine its role as part of a comprehensive risk factor management strategy for AF in obese patients.

Item Type:	Article
Uncontrolled Keywords:	Atrial fibrillation, Obesity, Cardiac risk factors, Fat
Depositing User:	Symplectic Admin
Date Deposited:	02 Mar 2021 15:21
Last Modified:	18 Jan 2023 22:57
DOI:	10.1093/ehjcvp/pvaa013
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3116395