Regenerative medicine therapies: lessons from the kidney.

Davies, Jamie A, Murray, Patricia and Wilm, Bettina
(2020) Regenerative medicine therapies: lessons from the kidney. Current opinion in physiology, 14. 41 - 47.

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We focus on three strategies for renal regenerative medicine; administering cells to replace damaged tissue, promoting endogenous regeneration, and growing stem cell-derived organs. Mouse kidney regeneration can be promoted by stem cells injected into the circulation which do not become new kidney tissue but seem to secrete regeneration-promoting humoral factors. This argues against direct replacement but encourages developing pharmacological stimulators of endogenous regeneration. Simple 'kidneys' have been made from stem cells, but there is a large gap between what has been achieved and a useful transplantable organ. Most current work aims to stimulate endogenous regeneration or to grow new organs but much remains to be done; misplaced hype about short-term prospects of regenerative medicine helps neither researchers nor patients.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 09 Mar 2021 15:51
Last Modified: 03 Jun 2021 07:13
DOI: 10.1016/j.cophys.2019.12.008