Davies, Jamie A, Murray, Patricia 
ORCID: 0000-0003-1316-148X and Wilm, Bettina ORCID: 0000-0002-9245-993X
(2020)
Regenerative medicine therapies: lessons from the kidney.
CURRENT OPINION IN PHYSIOLOGY, 14.
pp. 41-47.
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Abstract
We focus on three strategies for renal regenerative medicine; administering cells to replace damaged tissue, promoting endogenous regeneration, and growing stem cell-derived organs. Mouse kidney regeneration can be promoted by stem cells injected into the circulation which do not become new kidney tissue but seem to secrete regeneration-promoting humoral factors. This argues against direct replacement but encourages developing pharmacological stimulators of endogenous regeneration. Simple 'kidneys' have been made from stem cells, but there is a large gap between what has been achieved and a useful transplantable organ. Most current work aims to stimulate endogenous regeneration or to grow new organs but much remains to be done; misplaced hype about short-term prospects of regenerative medicine helps neither researchers nor patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Kidney Disease, Transplantation, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Regenerative Medicine, 5 Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Renal and urogenital, Generic health relevance |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Mar 2021 15:51 |
| Last Modified: | 14 Mar 2024 20:10 |
| DOI: | 10.1016/j.cophys.2019.12.008 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3116858 |
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