Nitric Oxide Releasing Implants for Orthopaedic Applications



Li, Man
(2021) Nitric Oxide Releasing Implants for Orthopaedic Applications. PhD thesis, University of Liverpool.

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Abstract

The pathogenesis of many orthopaedic infections is related to the presence of biofilms on device surfaces, which are currently combatted, primarily by use conventional antibiotic therapies once the infection has occurred. However, the overuse and misuse of antibiotics has led to antimicrobial resistance (AMR) and therefore it is of great important to develop non-antibiotic approaches to efficiently treat biofilm-related bacterial infection for orthopaedic applications. In this study, two different materials were investigated that are relevant to orthopaedic applications: titanium (Ti, non-degradable) and polycaprolactone/gelatine (PCL/GT, degradable). NO is used as an efficient antibacterial and antibiofilm agent as well as acting as a regulator of bone tissue engineering. Three NO-releasing systems have been designed and fabricated...

Item Type: Thesis (PhD)
Divisions: Faculty of Science and Engineering > School of Engineering
Depositing User: Symplectic Admin
Date Deposited: 26 Mar 2021 09:45
Last Modified: 23 Jul 2022 22:20
DOI: 10.17638/03116942
Supervisors:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3116942