Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance



Ferrara, Mariantonia, Lugano, Gaia ORCID: 0000-0002-3068-7339, Sandinha, Maria Teresa, Kearns, Victoria R ORCID: 0000-0003-1426-6048, Geraghty, Brendan ORCID: 0000-0003-0561-6667 and Steel, David HW
(2021) Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance. EYE, 35 (7). pp. 1818-1832.

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Abstract

Studying the biomechanical properties of biological tissue is crucial to improve our understanding of disease pathogenesis. The biomechanical characteristics of the cornea, sclera and the optic nerve head have been well addressed with an extensive literature and an in-depth understanding of their significance whilst, in comparison, knowledge of the retina and choroid is relatively limited. Knowledge of these tissues is important not only to clarify the underlying pathogenesis of a wide variety of retinal and vitreoretinal diseases, including age-related macular degeneration, hereditary retinal dystrophies and vitreoretinal interface diseases but also to optimise the surgical handling of retinal tissues and, potentially, the design and properties of implantable retinal prostheses and subretinal therapies. Our aim with this article is to comprehensively review existing knowledge of the biomechanical properties of retina, internal limiting membrane (ILM) and the Bruch's membrane-choroidal complex (BMCC), highlighting the potential implications for clinical and surgical practice. Prior to this we review the testing methodologies that have been used both in vitro, and those starting to be used in vivo to aid understanding of their results and significance.

Item Type: Article
Uncontrolled Keywords: Optic Disk, Retina, Choroid, Bruch Membrane, Humans, Macular Degeneration
Depositing User: Symplectic Admin
Date Deposited: 10 Mar 2021 16:04
Last Modified: 18 Jan 2023 22:56
DOI: 10.1038/s41433-021-01437-w
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3116948