Semakula, Jerome, Kisa, Geraldine, Mouton, Johannes, Cohen, Karen, Blockman, Marc, Pirmohamed, Munir 
ORCID: 0000-0002-7534-7266, Sekaggya-Wiltshire, Christine and Waitt, Catriona ORCID: 0000-0003-0134-5855
(2021)
Anticoagulation in sub-Saharan Africa: Are Direct Oral Anticoagulants the answer? A review of lessons learnt from warfarin
British Journal of Clinical Pharmacology, 87 (10).
pp. 3699-3705.
ISSN 0306-5251, 1365-2125
Abstract
Warfarin has existed for >7 decades and has been the anticoagulant of choice for many thromboembolic disorders. The recent introduction of direct-acting oral anticoagulants (DOACs) has, however, caused a shift in preference by healthcare professionals all over the world. DOACs have been found to be at least as effective as warfarin in prevention of stroke in patients with atrial fibrillation and in treatment of venous thromboembolism. In sub-Saharan Africa, however, the widespread use of DOACs has been hampered mainly by their higher acquisition costs. As the drugs come off patent, their use in sub-Saharan Africa is likely to increase. However, very few trials have been conducted in African settings, and safety concerns will need to be addressed with further study before widespread adoption into clinical practice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cardiovascular disease, direct oral anticoagulants, sub‐, Saharan Africa, warfarin |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 15 Mar 2021 11:25 |
| Last Modified: | 01 Mar 2026 09:51 |
| DOI: | 10.1111/bcp.14796 |
| Open Access URL: | https://bpspubs.onlinelibrary.wiley.com/doi/full/1... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3117352 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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