Leather, Thomas
(2021)
Magnetic resonance imaging and spectroscopic markers for the detection and metabolic characterisation of IDH-mutant gliomas
PhD thesis, University of Liverpool.
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Abstract
Background: The discovery of mutations in the isocitrate dehydrogenase (IDH) 1/2 gene induced a paradigm shift in the determination of diagnosis, prognosis and treatment of glioma. In 2016 the World Health Organisation (WHO) incorporated mutations in IDH1/2 into the diagnostic criteria for intracranial tumours as they have been demonstrated in 70-80% of WHO grade II-III gliomas, as well as in grade IV secondary glioblastoma (GBM)1 . Methods: This thesis explores several methods to further investigate and understand the noninvasive detection of IDH mutation as well as the pathophysiology of the mutation. Firstly, the extraction of quantitative features from MR images of glioma patients, and the subsequent application of machine learning strategies in order to carry out non-invasive classification according the IDH mutational status. Second was use a metabolomics analytical approach to 1 and 2 dimensional NMR spectroscopy to understand the metabolic implications of the presence of the mutation. Finally, the exploration of the utility of a novel magnetic resonance spectroscopy (MRS) sequence for the non-invasive detection of the IDH mutation induced oncometaboite 2-hydroxygluerate (2-HG). Results: The use of ... (continues)
| Item Type: | Thesis (PhD) |
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| Divisions: | Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 26 Mar 2021 09:54 |
| Last Modified: | 03 Feb 2025 18:16 |
| DOI: | 10.17638/03118009 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3118009 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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