Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease

Sinclair, Eleanor, Trivedi, Drupad K, Sarkar, Depanjan, Walton-Doyle, Caitlin, Milne, Joy, Kunath, Tilo, Rijs, Anouk M, de Bie, Rob MA, Goodacre, Royston ORCID: 0000-0003-2230-645X, Silverdale, Monty
et al (show 1 more authors) (2021) Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease. NATURE COMMUNICATIONS, 12 (1). 1592-.

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Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Pathway enrichment analysis shows alterations in lipid metabolism related to the carnitine shuttle, sphingolipid metabolism, arachidonic acid metabolism and fatty acid biosynthesis. This study shows sebum can be used to identify potential biomarkers for PD.

Item Type: Article
Uncontrolled Keywords: Sebum, Humans, Parkinson Disease, Lipids, Fatty Acids, Arachidonic Acid, Sphingolipids, Carnitine, Chromatography, Liquid, Aged, Middle Aged, Female, Male, Lipid Metabolism, Mass Spectrometry, Metabolomics, Biomarkers
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 31 Mar 2021 15:11
Last Modified: 18 Jan 2023 22:54
DOI: 10.1038/s41467-021-21669-4
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