Sinclair, Eleanor, Trivedi, Drupad K, Sarkar, Depanjan, Walton-Doyle, Caitlin, Milne, Joy, Kunath, Tilo, Rijs, Anouk M, de Bie, Rob MA, Goodacre, Royston 
ORCID: 0000-0003-2230-645X, Silverdale, Monty et al (show 1 more authors)
(2021)
Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease.
NATURE COMMUNICATIONS, 12 (1).
1592-.
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Pathway enrichment analysis shows alterations in lipid metabolism related to the carnitine shuttle, sphingolipid metabolism, arachidonic acid metabolism and fatty acid biosynthesis. This study shows sebum can be used to identify potential biomarkers for PD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Sebum, Humans, Parkinson Disease, Lipids, Fatty Acids, Arachidonic Acid, Sphingolipids, Carnitine, Chromatography, Liquid, Aged, Middle Aged, Female, Male, Lipid Metabolism, Mass Spectrometry, Metabolomics, Biomarkers |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 31 Mar 2021 15:11 |
| Last Modified: | 18 Jan 2023 22:54 |
| DOI: | 10.1038/s41467-021-21669-4 |
| Open Access URL: | https://www.nature.com/articles/s41467-021-21669-4 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3118233 |
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