Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

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Yates, T, Zaccardi, F, Islam, N, Razieh, C ORCID: 0000-0003-3597-2945, Gillies, CL, Lawson, CA, Chudasama, Y, Rowlands, A, Davies, MJ, Docherty, AB et al (show 90 more authors) , Openshaw, PJM, Baillie, JK, Semple, MG ORCID: 0000-0001-9700-0418, Khunti, K, Carson, G, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Cooke, GS, Dunning, J, da Silva Filipe, A, Fletcher, T, Green, CA, Harrison, EM, Hiscox, JA ORCID: 0000-0002-6582-0275, Ho, AYW, Horby, PW, Ijaz, S, Khoo, S ORCID: 0000-0002-2769-0967, Klenerman, P, Law, A, Lim, WS, Mentzer, AJ, Merson, L, Meynert, AM, Noursadeghi, M, Moore, SC ORCID: 0000-0001-8610-2806, Palmarini, M, Paxton, WA ORCID: 0000-0001-5200-0801, Pollakis, G ORCID: 0000-0002-9659-5461, Price, N, Rambaut, A, Robertson, DL, Russell, CD, Sancho-Shimizu, V, Scott, JT, Sigfrid, L, Solomon, T ORCID: 0000-0001-7266-6547, Sriskandan, S, Stuart, D, Summers, C, Tedder, RS, Thomson, EC, Thwaites, RS, Turtle, LCW ORCID: 0000-0002-0778-1693, Zambon, M, Hardwick, H, Donohue, C ORCID: 0000-0001-6379-8214, Ewins, J, Oosthuyzen, W, Griffiths, F, Norman, L, Pius, R, Drake, TM, Fairfield, CJ, Knight, S, Mclean, KA, Murphy, D, Shaw, CA, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C ORCID: 0000-0002-3021-1955, Leeming, G ORCID: 0000-0002-5554-5302, Law, A, Hendry, R, Scott-Brown, J, Greenhalf, W ORCID: 0000-0002-1865-3195, Shaw, V ORCID: 0000-0002-0429-0186, McDonald, S, Ahmed, KA, Armstrong, JA, Ashworth, M, Asiimwe, IG ORCID: 0000-0002-1196-1822, Bakshi, S, Barlow, SL, Booth, L, Brennan, B, Bullock, K ORCID: 0000-0002-5758-0179, Catterall, BWA ORCID: 0000-0002-6751-4300, Clark, JJ and Clarke, EA (2021) Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort Obesity, 29 (7). pp. 1223-1230. ISSN 1930-7381, 1930-739X

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Abstract

Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

Item Type:	Article
Uncontrolled Keywords:	ISARIC4C investigators, Humans, Obesity, Respiration, Artificial, Critical Care, Hospitalization, Hospital Mortality, Odds Ratio, Cohort Studies, Comorbidity, Minority Groups, Adult, Aged, Middle Aged, Female, Male, Young Adult, United Kingdom, COVID-19, Ethnicity
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	09 Apr 2021 08:14
Last Modified:	28 Feb 2026 23:41
DOI:	10.1002/oby.23178
Open Access URL:	http://doi.org/10.1002/oby.23178
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3118759
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