Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

Law, Alice E, Shears, Rebecca K, Lopez Rodas, Andrea A, Grencis, Richard K, Cooper, Philip J, Neill, Daniel R and Kadioglu, Aras ORCID: 0000-0003-1137-6321 (2021) Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease SCIENTIFIC REPORTS, 11 (1). 6984-. ISSN 2045-2322, 2045-2322

Text Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive dis.pdf - Published version Download (1MB) | Preview

Abstract

Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.

Item Type:	Article
Uncontrolled Keywords:	Animals, Humans, Mice, Streptococcus pneumoniae, Pneumococcal Infections, Helminthiasis, Intestinal Diseases, Parasitic, Risk Factors, Child, Child, Preschool, Ecuador, Female, Male, Coinfection
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	13 Apr 2021 15:00
Last Modified:	16 Jun 2026 08:56
DOI:	10.1038/s41598-021-86508-4
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3119168
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.