Law, Alice E, Shears, Rebecca K, Lopez Rodas, Andrea A, Grencis, Richard K, Cooper, Philip J, Neill, Daniel R 
ORCID: 0000-0002-7911-8153 and Kadioglu, Aras ORCID: 0000-0003-1137-6321
(2021)
Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease.
SCIENTIFIC REPORTS, 11 (1).
6984-.
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Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive dis.pdf - Published version Download (1MB) | Preview |
Abstract
Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Humans, Mice, Streptococcus pneumoniae, Pneumococcal Infections, Helminthiasis, Intestinal Diseases, Parasitic, Risk Factors, Child, Child, Preschool, Ecuador, Female, Male, Coinfection |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Apr 2021 15:00 |
| Last Modified: | 18 Jan 2023 22:53 |
| DOI: | 10.1038/s41598-021-86508-4 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3119168 |
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