An integrative analysis of the age-associated multi-omic landscape across cancers

Chatsirisupachai, Kasit ORCID: 0000-0001-9446-6714, Lesluyes, Tom, Paraoan, Luminita ORCID: 0000-0001-7568-7116, Van Loo, Peter and de Magalhães, João Pedro ORCID: 0000-0002-6363-2465 (2021) An integrative analysis of the age-associated multi-omic landscape across cancers. Nature Communications, 12 (1). 2345-.

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Official URL: http://dx.doi.org/10.1038/s41467-021-22560-y

Abstract

<jats:title>Abstract</jats:title><jats:p>Age is the most important risk factor for cancer, as cancer incidence and mortality increase with age. However, how molecular alterations in tumours differ among patients of different age remains largely unexplored. Here, using data from The Cancer Genome Atlas, we comprehensively characterise genomic, transcriptomic and epigenetic alterations in relation to patients’ age across cancer types. We show that tumours from older patients present an overall increase in genomic instability, somatic copy-number alterations (SCNAs) and somatic mutations. Age-associated SCNAs and mutations are identified in several cancer-driver genes across different cancer types. The largest age-related genomic differences are found in gliomas and endometrial cancer. We identify age-related global transcriptomic changes and demonstrate that these genes are in part regulated by age-associated DNA methylation changes. This study provides a comprehensive, multi-omics view of age-associated alterations in cancer and underscores age as an important factor to consider in cancer research and clinical practice.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	Humans, Neoplasms, Genomic Instability, Risk Factors, Gene Expression Profiling, Genomics, Age Factors, Signal Transduction, DNA Methylation, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Gene Duplication, Aging, Mutation, Loss of Heterozygosity, Oncogenes, Genome, Human, Databases, Genetic, Female, Male, DNA Copy Number Variations, Whole Genome Sequencing
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	22 Apr 2021 09:52
Last Modified:	18 Jan 2023 22:51
DOI:	10.1038/s41467-021-22560-y
Open Access URL:	https://doi.org/10.1038/s41467-021-22560-y
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3120160