One-year clinical outcome of patients with nonvalvular atrial fibrillation: Insights from KERALA-AF registry.



Bahuleyan, CG, Namboodiri, Narayanan, Jabir, A, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Koshy A, George, Shifas, Babu M, Viswanathan S, Kartik, Zachariah, Geevar, Venugopal, K, Punnose, Eapen
et al (show 17 more authors) (2021) One-year clinical outcome of patients with nonvalvular atrial fibrillation: Insights from KERALA-AF registry. Indian heart journal, 73 (1). 56 - 62.

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Abstract

<h4>Background</h4>We report patient characteristics, treatment pattern and one-year clinical outcome of nonvalvular atrial fibrillation (NVAF) from Kerala, India. This cohort forms part of Kerala Atrial Fibrillation (KERALA-AF) registry which is an ongoing large prospective study.<h4>Methods</h4>KERALA-AF registry collected data of adults with previously or newly diagnosed atrial fibrillation (AF) during April 2016 to April 2017. A total of 3421 patients were recruited from 53 hospitals across Kerala state. We analysed one-year follow-up outcome of 2507 patients with NVAF.<h4>Results</h4>Mean age at recruitment was 67.2 years (range 18-98) and 54.8% were males. Main co-morbidities were hypertension (61.2%), hyperlipidaemia (46.2%) and diabetes mellitus (37.2%). Major co-existing diseases were chronic kidney disease (42.1%), coronary artery disease (41.6%), and chronic heart failure (26.4%). Mean CHA<sub>2</sub>DS<sub>2</sub>-VASc score was 3.18 (SD ± 1.7) and HAS-BLED score, 1.84 (SD ± 1.3). At baseline, use of oral anticoagulants (OAC) was 38.6% and antiplatelets 32.7%. On one-month follow-up use of OAC increased to 65.8% and antiplatelets to 48.3%. One-year all-cause mortality was 16.48 and hospitalization 20.65 per 100 person years. The main causes of death were cardiovascular (75.0%), stroke (13.1%) and others (11.9%). The major causes of hospitalizations were acute coronary syndrome (35.0%), followed by arrhythmia (29.5%) and heart failure (8.4%).<h4>Conclusions</h4>Despite high risk profile of patients in this registry, use of OAC was suboptimal, whereas antiplatelets were used in nearly half of patients. A relatively high rate of annual mortality and hospitalization was observed in patients with NVAF in Kerala AF Registry.

Item Type: Article
Uncontrolled Keywords: Humans, Atrial Fibrillation, Anticoagulants, Administration, Oral, Registries, Survival Rate, Follow-Up Studies, Prospective Studies, Dose-Response Relationship, Drug, Time Factors, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Stroke, Young Adult
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 27 Apr 2021 14:51
Last Modified: 18 Aug 2022 01:11
DOI: 10.1016/j.ihj.2020.11.152
URI: https://livrepository.liverpool.ac.uk/id/eprint/3120758