Geographical and Tick-Dependent Distribution of Flavi-Like Alongshan and Yanggou Tick Viruses in Russia

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Kholodilov, Ivan S, Belova, Oxana A, Morozkin, Evgeny S, Litov, Alexander G, Ivannikova, Anna Y, Makenov, Marat T, Shchetinin, Alexey M, Aibulatov, Sergey V, Bazarova, Galina K, Bell-Sakyi, Lesley ORCID: 0000-0002-7305-0477 et al (show 29 more authors) , Bespyatova, Liubov A, Bugmyrin, Sergey V, Chernetsov, Nikita, Chernokhaeva, Liubov L, Gmyl, Larissa V, Khaisarova, Anna N, Khalin, Alexei V, Klimentov, Alexander S, Kovalchuk, Irina V, Luchinina, Svetlana V, Medvedev, Sergey G, Nafeev, Alexander A, Oorzhak, Natalia D, Panjukova, Elena V, Polienko, Alexandra E, Purmak, Kristina A, Romanenko, Evgeniya N, Rozhdestvenskiy, Evgeniy N, Saryglar, Anna A, Shamsutdinov, Anton F, Solomashchenko, Nataliya I, Trifonov, Vladimir A, Volchev, Evgenii G, Vovkotech, Pavel G, Yakovlev, Alexander S, Zhurenkova, Olga B, Gushchin, Vladimir A, Karan, Lyudmila S and Karganova, Galina G (2021) Geographical and Tick-Dependent Distribution of Flavi-Like Alongshan and Yanggou Tick Viruses in Russia. VIRUSES-BASEL, 13 (3). 458-.

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Abstract

The genus <i>Flavivirus</i> includes related, unclassified segmented flavi-like viruses, two segments of which have homology with flavivirus RNA-dependent RNA polymerase NS5 and RNA helicase-protease NS3. This group includes such viruses as Jingmen tick virus, Alongshan virus, Yanggou tick virus and others. We detected the Yanggou tick virus in <i>Dermacentor nuttalli</i> and <i>Dermacentor marginatus</i> ticks in two neighbouring regions of Russia. The virus prevalence ranged from 0.5% to 8.0%. We detected RNA of the Alongshan virus in 44 individuals or pools of various tick species in eight regions of Russia. The virus prevalence ranged from 0.6% to 7.8%. We demonstrated the successful replication of the Yanggou tick virus and Alongshan virus in IRE/CTVM19 and HAE/CTVM8 tick cell lines without a cytopathic effect. According to the phylogenetic analysis, we divided the Alongshan virus into two groups: an <i>Ixodes persulcatus</i> group and an <i>Ixodes ricinus</i> group. In addition, the <i>I. persulcatus</i> group can be divided into European and Asian subgroups. We found amino acid signatures specific to the <i>I. ricinus</i> and <i>I. persulcatus</i> groups and also distinguished between the European and Asian subgroups of the <i>I. persulcatus</i> group.

Item Type:	Article
Uncontrolled Keywords:	Alongshan virus, Yanggou tick virus, Jingmen tick virus, Flavivirus, flavi-like virus, segmented virus, amino acid substitutions, tick cell line
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	27 Apr 2021 15:00
Last Modified:	18 Jan 2023 22:50
DOI:	10.3390/v13030458
Open Access URL:	https://www.mdpi.com/1999-4915/13/3/458
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3120760