Diet-induced reduction of left ventricular wall thickness, Troponin-I and IGF-1 in cats with asymptomatic hypertrophic cardiomyopathy.

van Hoek, I, Hodgkiss-Geere, H ORCID: 0000-0001-7561-8479, Bode, E, Hamilton-Elliott, J, Motskula, P, Palermo, V, Martinez-Pereira, Y, Culshaw, G, Laxalde, J and Dukes McEwan, Joanna ORCID: 0000-0002-0326-8251 (2020) Diet-induced reduction of left ventricular wall thickness, Troponin-I and IGF-1 in cats with asymptomatic hypertrophic cardiomyopathy. Journal of Veterinary Internal Medicine, 34 (6). pp. 2197-2210. ISSN 0891-6640

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Abstract

BACKGROUND: Cats with subclinical hypertrophic cardiomyopathy (sHCM) have elevated serum insulin and serum amyloid A concentrations correlating with the degree of cardiac hypertrophy. Diet might affect these and other cardiac variables. OBJECTIVE: Evaluate the effect of a complete, balanced diet with restricted starch and supplemented with eicosapentaenoic acid + docosahexaenoic acid (EPA + DHA) on echocardiographic variables and cardiac biomarkers in cats with sHCM. ANIMALS: Forty-four client-owned cats with sHCM. METHODS: A prospective, randomized, double-blind, multicenter study enrolled cats with end-diastole interventricular septum thickness (IVSd) or left ventricular wall thickness (LVWd) ≥6 mm, or both. Nonsedated, fasted cats were examined at baseline and after 6 and 12 months of Test (restricted starch and EPA + DHA supplements) (n = 23) or Control (unrestricted starch without EPA + DHA supplementation) (n = 21) diet. Assessments included auscultation, body weight, body condition score, echocardiography and blood analysis. Linear and generalized mixed models analyzed diet, time and diet * time interactions (5% significance level). RESULTS: No differences between diet groups were significant for any variable at any timepoint. There were significant decreases in the Test but not Control group in maximum IVSd (P = .03), maximum LVWd (P = .02) and insulin-like growth factor-1 levels (P = .04) after 12 months, and in ultrasensitive cardiac troponin I (cTnI) (P = .001) after 6 months; effect sizes (95% confidence interval) were 0.53 (0.09; 0.99), 0.63 (0.18; 1.09), 0.61 (0.16; 1.07), and 0.37 (-0.06; 0.8), respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: Cats with sHCM fed Test diet had significant decreases in echocardiographic variables of sHCM and in cTnI and IGF-1.

Item Type:	Article
Uncontrolled Keywords:	3009 Veterinary Sciences, 30 Agricultural, Veterinary and Food Sciences, Heart Disease, Pediatric Research Initiative, Cardiovascular, Nutrition, Dietary Supplements, Complementary and Integrative Health, Cardiovascular, Animals, Biomarkers, Cardiomyopathy, Hypertrophic, Cat Diseases, Cats, Diet, Insulin-Like Growth Factor I, Prospective Studies, Troponin I
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	19 May 2021 09:23
Last Modified:	16 Jan 2026 01:26
DOI:	10.1111/jvim.15925
Open Access URL:	https://doi.org/10.1111/jvim.15925
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3123281
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