The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating its Localisation, Stability and Activity



Albanese, Adam, Daly, Leonard A, Mennerich, Daniela, Kietzmann, Thomas and Sée, Violaine ORCID: 0000-0001-6384-8381
The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating its Localisation, Stability and Activity.

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Abstract

<jats:p>The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis. Whilst hydroxylation has been thoroughly described as the major and canonical modification of the HIF-&amp;alpha; subunits, regulating both HIF stability and activity, a range of other post-translational modifications decorating the entire protein play also a crucial role in altering HIF localisation, stability, and activity. These modifications, their conservation throughout evolution and their effects on HIF-dependent signalling are discussed in this review.</jats:p>

Item Type: Article
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 21 May 2021 08:16
Last Modified: 21 May 2021 08:16
DOI: 10.20944/preprints202012.0112.v1
Open Access URL: https://doi.org/10.3390/ijms22010268
URI: https://livrepository.liverpool.ac.uk/id/eprint/3123435