Oxygen in Metabolic Dysfunction and Its Therapeutic Relevance

Lopez-Pascual, Amaya, Trayhurn, Paul ORCID: 0000-0002-9940-283X, Alfredo Martinez, J and Gonzalez-Muniesa, Pedro
(2021) Oxygen in Metabolic Dysfunction and Its Therapeutic Relevance. ANTIOXIDANTS & REDOX SIGNALING, 35 (8). pp. 642-687.

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<b><i>Significance:</i></b> In recent years, a number of studies have shown altered oxygen partial pressure at a tissue level in metabolic disorders, and some researchers have considered oxygen to be a (macro) nutrient. Oxygen availability may be compromised in obesity and several other metabolism-related pathological conditions, including sleep apnea-hypopnea syndrome, the metabolic syndrome (which is a set of conditions), type 2 diabetes, cardiovascular disease, and cancer. <b><i>Recent Advances:</i></b> Strategies designed to reduce adiposity and its accompanying disorders have been mainly centered on nutritional interventions and physical activity programs. However, novel therapies are needed since these approaches have not been sufficient to counteract the worldwide increasing rates of metabolic disorders. In this regard, intermittent hypoxia training and hyperoxia could be potential treatments through oxygen-related adaptations. Moreover, living at a high altitude may have a protective effect against the development of abnormal metabolic conditions. In addition, oxygen delivery systems may be of therapeutic value for supplying the tissue-specific oxygen requirements. <b><i>Critical Issues:</i></b> Precise <i>in vivo</i> methods to measure oxygenation are vital to disentangle some of the controversies related to this research area. Further, it is evident that there is a growing need for novel <i>in vitro</i> models to study the potential pathways involved in metabolic dysfunction to find appropriate therapeutic targets. <b><i>Future Directions:</i></b> Based on the existing evidence, it is suggested that oxygen availability has a key role in obesity and its related comorbidities. Oxygen should be considered in relation to potential therapeutic strategies in the treatment and prevention of metabolic disorders. <i>Antioxid. Redox Signal.</i> 35, 642-687.

Item Type: Article
Uncontrolled Keywords: oxygenation, metabolism, chronic disease, hypoxia, hyperoxia
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 04 Mar 2022 10:15
Last Modified: 18 Jan 2023 22:37
DOI: 10.1089/ars.2019.7901
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3124352