Clinical outcomes of pre-loaded ultra-thin DSAEK and pre-loaded DMEK



Romano, Vito ORCID: 0000-0002-5148-7643, Pagano, Luca, Gadhvi, Kunal A, Coco, Giulia, Titley, Mitchell, Fenech, Matthew Thomas, Ferrari, Stefano, Levis, Hannah J ORCID: 0000-0002-3923-1178, Parekh, Mohit and Kaye, Stephen ORCID: 0000-0003-0390-0592
(2020) Clinical outcomes of pre-loaded ultra-thin DSAEK and pre-loaded DMEK. BMJ OPEN OPHTHALMOLOGY, 5 (1). e000546-.

[img] Text
Clinical outcomes of pre-loaded ultra-thin DSAEK and pre-loaded DMEK.pdf - Published version

Download (344kB) | Preview

Abstract

<h4>Objective</h4>To compare clinical outcomes and complications between pre-loaded ultra-thin Descemet stripping automated endothelialkeratoplasty (pl-UT-DSAEK) and pre-loaded Descemet membrane endothelial keratoplasty (pl-DMEK).<h4>Methods and analysis</h4>Comparative study in patients with endothelial dysfunction associated with Fuchs endothelial corneal dystrophy and pseudophakic bullous keratopathy who underwent pl-UT-DSAEK or pl-DMEK transplants. For both groups, the tissues were pre-loaded at the Fondazione Banca degli Occhi del Veneto (Venice, Italy) and shipped to The Royal Liverpool University Hospital (Liverpool, UK). Best corrected visual acuity (BCVA) and re-bubbling rates were the main outcome measures.<h4>Results</h4>56 eyes of 56 patients were included. 31 received pl-UT-DSAEK and 25 received pl-DMEK. At 12 months, BCVA (LogMAR) was significantly better for pl-DMEK (0.17±0.20 LogMAR) compared with pl-UT-DSAEK (0.37±0.37 LogMAR, p<0.01). The percentage of people that achieved ≥20/30 was significantly higher in the pl-DMEK group. The rate of re-bubbling, however, was significantly higher for pl-DMEK (44.0%) than for Pl-UT-DSAEK (12.9%), p<0.01.<h4>Conclusion</h4>Pl-DMEK offers better BCVA than pl-UT-DSAEK. The higher re-bubbling rate associated with pre-loaded DMEK is of concern.

Item Type: Article
Uncontrolled Keywords: cornea
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Clinical Directorate
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 02 Jun 2021 13:53
Last Modified: 18 Jan 2023 22:36
DOI: 10.1136/bmjophth-2020-000546
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3124895