Role of Hypoxia in the Control of the Cell Cycle

Druker, Jimena, Wilson, James W ORCID: 0000-0002-9373-6919, Child, Fraser, Shakir, Dilem, Fasanya, Temitope and Rocha, Sonia (2021) Role of Hypoxia in the Control of the Cell Cycle. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (9). 4874-.

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Official URL: http://dx.doi.org/10.3390/ijms22094874

Abstract

The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.

Item Type:	Article
Uncontrolled Keywords:	hypoxia, cell cycle, HIF, PHDs, 2-OGDs, mitosis
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	07 Jun 2021 15:18
Last Modified:	18 Jan 2023 22:35
DOI:	10.3390/ijms22094874
Open Access URL:	https://www.mdpi.com/1422-0067/22/9/4874
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3125476