Chaguza, Chrispin 
ORCID: 0000-0002-2108-1757, Senghore, Madikay, Bojang, Ebrima, Gladstone, Rebecca A, Lo, Stephanie W, Tientcheu, Peggy-Estelle, Bancroft, Rowan E, Worwui, Archibald, Foster-Nyarko, Ebenezer, Ceesay, Fatima et al (show 9 more authors)
(2020)
Within-host microevolution of <i>Streptococcus pneumoniae</i> is rapid and adaptive during natural colonisation.
NATURE COMMUNICATIONS, 11 (1).
3442-.
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Abstract
Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage. However, little is known about genomic changes during natural colonisation. Here, we use whole-genome sequencing to investigate within-host microevolution of naturally carried pneumococci in ninety-eight infants intensively sampled sequentially from birth until twelve months in a high-carriage African setting. We show that neutral evolution and nucleotide substitution rates up to forty-fold faster than observed over longer timescales in S. pneumoniae and other bacteria drives high within-host pneumococcal genetic diversity. Highly divergent co-existing strain variants emerge during colonisation episodes through real-time intra-host homologous recombination while the rest are co-transmitted or acquired independently during multiple colonisation episodes. Genic and intergenic parallel evolution occur particularly in antibiotic resistance, immune evasion and epithelial adhesion genes. Our findings suggest that within-host microevolution is rapid and adaptive during natural colonisation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Streptococcus pneumoniae, Pneumococcal Infections, Genetics, Evolution, Molecular, Genome, Bacterial, Whole Genome Sequencing |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 17 Jun 2021 14:00 |
| Last Modified: | 10 Oct 2023 06:05 |
| DOI: | 10.1038/s41467-020-17327-w |
| Open Access URL: | https://www.nature.com/articles/s41467-020-17327-w |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3126741 |
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