Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx).



van Oort, Pouline Mp ORCID: 0000-0002-2719-8817, Nijsen, Tamara M, White, Iain R, Knobel, Hugo H, Felton, Timothy ORCID: 0000-0001-6868-6633, Rattray, Nicholas, Lawal, Oluwasola, Bulut, Murtaza, Ahmed, Waqar, Artigas, Antonio
et al (show 9 more authors) (2021) Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx). Thorax.

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Abstract

Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.

Item Type: Article
Uncontrolled Keywords: BreathDx Consortium
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 18 Jun 2021 15:42
Last Modified: 04 Oct 2021 05:10
DOI: 10.1136/thoraxjnl-2021-217362
Open Access URL: https://thorax.bmj.com/content/early/2021/06/03/th...
URI: https://livrepository.liverpool.ac.uk/id/eprint/3126846