van Oort, Pouline MP, Nijsen, Tamara M, White, Iain R, Knobel, Hugo H, Felton, Timothy, Rattray, Nicholas, Lawal, Oluwasola, Bulut, Murtaza, Ahmed, Waqar, Artigas, Antonio et al (show 8 more authors)
(2022)
Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx).
THORAX, 77 (1).
pp. 79-81.
ISSN 0040-6376, 1468-3296
Abstract
Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | pneumonia, assisted ventilation, critical care |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 18 Jun 2021 15:42 |
| Last Modified: | 07 Dec 2024 22:58 |
| DOI: | 10.1136/thoraxjnl-2021-217362 |
| Open Access URL: | https://thorax.bmj.com/content/early/2021/06/03/th... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3126846 |
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