Ferdousi, M, Kalteniece, A, Petropoulos, I, Azmi, S, Dhage, S, Marshall, A 
ORCID: 0000-0001-8273-7089, Boulton, AJM, Efron, N, Faber, CG, Lauria, G et al (show 2 more authors)
(2020)
Diabetic neuropathy is characterized by progressive corneal nerve fiber loss in the central and inferior whorl regions
Investigative Ophthalmology and Visual Science, 61 (3).
48-.
ISSN 0146-0404, 1552-5783
Abstract
PURPOSE. We hypothesized that longitudinal changes in corneal nerve morphology would differ between the central cornea and inferior whorl in relation to other measures of diabetic neuropathy. METHODS. Thirty patients with diabetes (age: 54.08 ± 15.86, duration: 23.95 ± 14.2, HbA1c: 7.51 ± 1.37) and 19 age-matched healthy controls (age: 49.47 ± 13.25) underwent assessment of neuropathy disability score (NDS), vibration perception threshold (VPT), cold (CPT) and warm (WPT) perception thresholds, peroneal motor nerve conduction velocity (PMNCV), corneal nerve fiber density (CNFD), branch density (CNBD), fiber length (CNFL), inferior whorl length (IWL), and the average of CNFL and IWL (ANFL) at baseline and after 1 to 8 years. RESULTS. In patients with diabetes, between baseline and follow-up, there was a significant reduction in CNBD (57.72 ± 30.08 vs. 44.04 ± 23.69; P = 0.02), CNFL (21.77 ± 5.19 vs. 15.65 ± 4.7; P < 0.0001), IWL (24.69 ± 8.67 vs. 14.23 ± 6.13; P < 0.0001), ANFL (23.26 ± 5.53 vs. 15.09 ± 4.48; P < 0.0001), and WPT (43.56 ± 4.43 vs. 40.78 ± 4.93; P = 0.01), and an increase in VPT (12.9 ± 8.96 vs. 13.78 ± 8.99; P = 0.02). There was no significant change in CNFD (27.12 ± 8.2 vs. 25.43 ± 7.11; P = 0.2), NDS (3.38 ± 3.35 vs. 2.61 ± 2.8; P = 0.08), CPT (17.7 ± 10.59 vs. 22.45 ± 9.23; P = 0.06), or PMNCV (42.4 ± 4.21 vs. 42.16 ± 6.3; P = 0.2). CONCLUSIONS. There is evidence of corneal nerve loss in patients with diabetes, particularly at the inferior whorl during follow-up.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Nerve Fibers, Trigeminal Nerve, Cornea, Humans, Trigeminal Nerve Diseases, Diabetic Neuropathies, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Microscopy, Confocal, Body Mass Index, Blood Pressure, Adult, Aged, Middle Aged, Female, Male, Glycated Hemoglobin |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 Jun 2021 08:21 |
| Last Modified: | 24 Jan 2026 02:34 |
| DOI: | 10.1167/iovs.61.3.48 |
| Open Access URL: | https://doi.org/10.1167/iovs.61.3.48 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3127668 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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