Diabetic Neuropathy Is Characterized by Progressive Corneal Nerve Fiber Loss in the Central and Inferior Whorl Regions.


Ferdousi, Maryam ORCID: 0000-0002-7989-8233, Kalteniece, Alise, Petropoulos, Ioannis, Azmi, Shazli, Dhage, Shaishav, Marshall, Andrew ORCID: 0000-0001-8273-7089, Boulton, Andrew JM, Efron, Nathan, Faber, Catharina G, Lauria, Giuseppe ORCID: 0000-0001-9773-020X et al (show 2 more authors) (2020) Diabetic Neuropathy Is Characterized by Progressive Corneal Nerve Fiber Loss in the Central and Inferior Whorl Regions. Investigative ophthalmology & visual science, 61 (3). 48-. ISSN 0146-0404, 1552-5783

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Abstract

<h4>Purpose</h4>We hypothesized that longitudinal changes in corneal nerve morphology would differ between the central cornea and inferior whorl in relation to other measures of diabetic neuropathy.<h4>Methods</h4>Thirty patients with diabetes (age: 54.08 ± 15.86, duration: 23.95 ± 14.2, HbA1c: 7.51 ± 1.37) and 19 age-matched healthy controls (age: 49.47 ± 13.25) underwent assessment of neuropathy disability score (NDS), vibration perception threshold (VPT), cold (CPT) and warm (WPT) perception thresholds, peroneal motor nerve conduction velocity (PMNCV), corneal nerve fiber density (CNFD), branch density (CNBD), fiber length (CNFL), inferior whorl length (IWL), and the average of CNFL and IWL (ANFL) at baseline and after 1 to 8 years.<h4>Results</h4>In patients with diabetes, between baseline and follow-up, there was a significant reduction in CNBD (57.72 ± 30.08 vs. 44.04 ± 23.69; P = 0.02), CNFL (21.77 ± 5.19 vs. 15.65 ± 4.7; P < 0.0001), IWL (24.69 ± 8.67 vs. 14.23 ± 6.13; P < 0.0001), ANFL (23.26 ± 5.53 vs. 15.09 ± 4.48; P < 0.0001), and WPT (43.56 ± 4.43 vs. 40.78 ± 4.93; P = 0.01), and an increase in VPT (12.9 ± 8.96 vs. 13.78 ± 8.99; P = 0.02). There was no significant change in CNFD (27.12 ± 8.2 vs. 25.43 ± 7.11; P = 0.2), NDS (3.38 ± 3.35 vs. 2.61 ± 2.8; P = 0.08), CPT (17.7 ± 10.59 vs. 22.45 ± 9.23; P = 0.06), or PMNCV (42.4 ± 4.21 vs. 42.16 ± 6.3; P = 0.2).<h4>Conclusions</h4>There is evidence of corneal nerve loss in patients with diabetes, particularly at the inferior whorl during follow-up.

Item Type: Article
Uncontrolled Keywords: Nerve Fibers, Trigeminal Nerve, Cornea, Humans, Trigeminal Nerve Diseases, Diabetic Neuropathies, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Microscopy, Confocal, Body Mass Index, Blood Pressure, Adult, Aged, Middle Aged, Female, Male, Glycated Hemoglobin
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 25 Jun 2021 08:21
Last Modified: 07 Dec 2024 09:51
DOI: 10.1167/iovs.61.3.48
Open Access URL: https://doi.org/10.1167/iovs.61.3.48
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3127668
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