Hughes, Karen 
ORCID: 0000-0002-8517-8996
(2021)
Methods to assess and improve the uptake of core outcome sets.
Doctor of Philosophy thesis, University of Liverpool.
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Abstract
Introduction and aims: Core outcomes sets (COS) are agreed, standardised sets of outcomes that should be measured and reported, as a minimum, in all clinical trials of a specific area of health or health care. COS have the potential to reduce research waste by improving the selection and reporting of outcomes in randomised controlled trials (RCTs), but this reduction in waste will only be realised if researchers choosing outcomes for RCTs include COS in their studies. The continuous development of COS, without uptake, could itself result in research waste. This thesis examined the extent to which COS are used across different areas of health, also investigating the methods used to assess uptake, and explored barriers and facilitators to the implementation of COS to inform the development of interventions to improve uptake. Methods: A systematic review to identify studies that had evaluated the uptake of a COS was undertaken. An assessment of citation analysis as an approach to assess COS uptake was carried out. A review of National Institute for Health Research Health Technology Assessment (NIHR HTA) RCT funding applications was undertaken, followed by a survey of chief investigators (CIs), to investigate ... (continues)
| Item Type: | Thesis (Doctor of Philosophy) |
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| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Sep 2021 12:53 |
| Last Modified: | 26 Oct 2024 21:59 |
| DOI: | 10.17638/03128102 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3128102 |
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