Ras Variant Biology and Contributions to Human Disease.



Prior, Ian ORCID: 0000-0002-4055-5161
(2021) Ras Variant Biology and Contributions to Human Disease. Methods in molecular biology (Clifton, N.J.), 2262. 3 - 18.

[img] Text
Ras variant biology.pdf - Accepted Version
Access to this file is embargoed until 12 May 2022.

Download (740kB)

Abstract

Analysis of cancer and RASopathy genetic databases reveals that ~19% of all cancer cases and ~4% of developmental disorders contain Ras mutations. Ras isoform and mutation variants differentially contribute to these diseases and provide an opportunity for deeper understanding of Ras function. The putative mechanisms underpinning these differences, new approaches that are being applied, and some of the key questions and challenges that remain are discussed.

Item Type: Article
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 29 Jun 2021 08:34
Last Modified: 02 Oct 2021 21:10
DOI: 10.1007/978-1-0716-1190-6_1
URI: https://livrepository.liverpool.ac.uk/id/eprint/3128106