Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19

Brain, Danielle ORCID: 0000-0002-1671-8477, Plant-Hately, Alex ORCID: 0000-0003-2425-1990, Heaton, Bethany ORCID: 0000-0002-1495-1945, Arshad, Usman ORCID: 0000-0003-1586-1885, David, Christopher ORCID: 0000-0001-8504-2354, Hedrich, Christian ORCID: 0000-0002-1295-6179, Owen, Andrew ORCID: 0000-0002-9819-7651 and Liptrott, Neill J ORCID: 0000-0002-5980-8966 (2021) Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19. ADVANCED DRUG DELIVERY REVIEWS, 178. 113848-.

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Abstract

The emergence of SARS-CoV-2, and the ensuing global pandemic, has resulted in an unprecedented response to identify therapies that can limit uncontrolled inflammation observed in patients with moderate to severe COVID-19. The immune pathology behind COVID-19 is complex and involves the activation and interaction of multiple systems including, but not limited to, complement, inflammasomes, endothelial as well as innate and adaptive immune cells to bring about a convoluted profile of inflammation, coagulation and tissue damage. To date, therapeutic approaches have focussed on inhibition of coagulation, untargeted immune suppression and/or cytokine-directed blocking agents. Regardless of recently achieved improvements in individual patient outcomes and survival rates, improved and focussed approaches targeting individual systems involved is needed to further improve prognosis and wellbeing. This review summarizes the current understanding of molecular and cellular systems involved in the pathophysiology of COVID-19, and their contribution to pathogen clearance and damage to then discuss possible therapeutic options involving immunomodulatory drug delivery systems as well as summarising the complex interplay between them.

Item Type:	Article
Uncontrolled Keywords:	Complement, COVID-19, Endothelium, Inflammasome, Nanomedicine, SARS-CoV-2
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	29 Jun 2021 10:52
Last Modified:	28 Mar 2023 10:49
DOI:	10.1016/j.addr.2021.113848
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3128119