Acute Dental Periapical Abscess and New-Onset Atrial Fibrillation: A Nationwide, Population-Based Cohort Study



Hassan, Amaar Obaid ORCID: 0000-0002-3051-2037, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Bisson, Arnaud ORCID: 0000-0002-3449-1800, Herbert, Julien, Bodin, Alexandre, Fauchier, Laurent and Harris, Rebecca V ORCID: 0000-0002-5891-6826
(2021) Acute Dental Periapical Abscess and New-Onset Atrial Fibrillation: A Nationwide, Population-Based Cohort Study. JOURNAL OF CLINICAL MEDICINE, 10 (13). 2927-.

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Abstract

There are limited data on the relationship of acute dental infections with hospitalisation and new-onset atrial fibrillation (AF). This study aimed to assess the relationship between acute periapical abscess and incident AF. This was a retrospective cohort study from a French national database of patients hospitalized in 2013 (3.4 million patients) with at least five years of follow up. In total, 3,056,291 adults (55.1% female) required hospital admission in French hospitals in 2013 while not having a history of AF. Of 4693 patients classified as having dental periapical abscess, 435 (9.27%) developed AF, compared to 326,241 (10.69%) without dental periapical abscess that developed AF over a mean follow-up of 4.8 ± 1.7 years. Multivariable analysis indicated that dental periapical abscess acted as an independent predictor for new onset AF (<i>p</i> < 0.01). The CHA<sub>2</sub>DS<sub>2</sub>VASc score in patients with acute dental periapical abscess had moderate predictive value for development of AF, with Area Under the Curve (AUC) 0.73 (95% CI, 0.71-0.76). An increased risk of new onset AF was identified for individuals hospitalized with dental periapical abscess. Careful follow up of patients with severe, acute dental periapical infections is needed for incident AF, as well as investigations of possible mechanisms linking these conditions.

Item Type: Article
Uncontrolled Keywords: atrial fibrillation, periapical abscess, oral health, acute dental infection, cardiovascular disease
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Clinical Directorate
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 01 Jul 2021 12:47
Last Modified: 01 Feb 2024 00:46
DOI: 10.3390/jcm10132927
Open Access URL: https://www.mdpi.com/2077-0383/10/13/2927
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3128415