Modeling the metabolic profile of <i>Mytilus edulis</i> reveals molecular signatures linked to gonadal development, sex and environmental site

Kronberg, Jaanika, Byrne, Jonathan J, Jansen, Jeroen, Antczak, Philipp ORCID: 0000-0001-9600-7757, Hines, Adam, Bignell, John, Katsiadaki, Ioanna, Viant, Mark R and Falciani, Francesco ORCID: 0000-0003-1432-2871 (2021) Modeling the metabolic profile of <i>Mytilus edulis</i> reveals molecular signatures linked to gonadal development, sex and environmental site. SCIENTIFIC REPORTS, 11 (1). 12882-.

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Official URL: http://dx.doi.org/10.1038/s41598-021-90494-y

Abstract

The monitoring of anthropogenic chemicals in the aquatic environment including their potential effects on aquatic organisms, is important for protecting life under water, a key sustainable development goal. In parallel with monitoring the concentrations of chemicals of concern, sentinel species are often used to investigate the biological effects of contaminants. Among these, bivalve molluscs such as mussels are filter-feeding and sessile, hence an excellent model system for measuring localized pollution. This study investigates the relationship between the metabolic state of the blue mussel (Mytilus edulis) and its physiology in different environments. We developed a computational model based on a reference site (relatively unpolluted) and integrated seasonal dynamics of metabolite relative concentrations with key physiological indicators and environmental parameters. The analysis of the model revealed that changes in metabolite levels during an annual cycle are influenced by water temperature and are linked to gonadal development. This work supports the importance of data-driven biology and its potential in environmental monitoring.

Item Type:	Article
Uncontrolled Keywords:	Gonads, Animals, Computational Biology, Environment, Seasons, Sex Factors, Sexual Development, Models, Theoretical, Mytilus edulis, Metabolomics, Metabolome, Biomarkers
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	01 Jul 2021 14:05
Last Modified:	18 Oct 2023 02:40
DOI:	10.1038/s41598-021-90494-y
Open Access URL:	https://doi.org/10.1038/s41598-021-90494-y
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3128430