Does Sleep Position Influence Sleep-Disordered Breathing in Infants With Cleft Palate: A Feasibility Study?

Murray, Clare S, Walsh, Tanya, Bannister, Trisha, Metryka, Aleksandra, Davies, Karen, Lin, Yin Ling, Williamson, Paula ORCID: 0000-0001-9802-6636, Callery, Peter, O'Brien, Kevin, Shaw, William
et al (show 1 more authors) (2022) Does Sleep Position Influence Sleep-Disordered Breathing in Infants With Cleft Palate: A Feasibility Study? CLEFT PALATE-CRANIOFACIAL JOURNAL, 59 (2). pp. 254-261.

Access the full-text of this item by clicking on the Open Access link.


<h4>Objective</h4>Cleft palate (CP) can affect breathing, leading to sleep-disordered breathing (SDB). Sleep position can affect SDB, but the optimum sleep position for infants with CP is unknown. We aimed to determine the design of a pragmatic study to investigate the effect of the 2 routinely advised sleep positions in infants with CP on oxygen saturations.<h4>Design</h4>A multicentered observational cohort.<h4>Setting</h4>Four UK-based cleft centers, 2 advising supine- and 2 side-lying sleep positions for infants with CP.<h4>Participants</h4>Infants with isolated CP born July 1, 2015, and December 31, 2016. Of 48 eligible infants, 30 consented (17 side-lying; 13 supine).<h4>Interventions</h4>Oxygen saturation (SpO<sub>2</sub>) and end-tidal carbon dioxide (ETCO<sub>2</sub>) home monitoring at age 1 and 3 months. Qualitative interviews of parents.<h4>Outcome measures</h4>Willingness to participate, recruitment, retention, and acceptability/success (>90 minutes recording) of SpO<sub>2</sub> and ETCO<sub>2</sub> monitoring.<h4>Results</h4>SpO<sub>2</sub> recordings were obtained during 50 sleep sessions on 24 babies (13 side-lying) at 1 month (34 sessions >90 minutes) and 50 sessions on 19 babies (10 side-lying) at 3 months (27 sessions >90 minutes). The ETCO<sub>2</sub> monitoring was only achieved in 12 sessions at 1 month and 6 at 3 months; only 1 was >90 minutes long. The ETCO<sub>2</sub> monitoring was reported by the majority as unacceptable. Parents consistently reported the topic of sleep position in CP to be of importance.<h4>Conclusions</h4>This study has demonstrated that it is feasible to perform domiciliary oxygen saturation studies in a research setting and has suggested that there may be a difference in the effects of sleep position that requires further investigation. We propose a study with randomization is indicated, comparing side-lying with supine-lying sleep position, representing an important step toward better understanding of SDB in infants with CP.

Item Type: Article
Uncontrolled Keywords: cleft palate, sleep-disordered breathing, oxygen saturation, infant sleep position
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 01 Jul 2021 14:51
Last Modified: 18 Jan 2023 21:37
DOI: 10.1177/10556656211003459
Open Access URL:
Related URLs: