Small High-Risk Uveal Melanomas Have a Lower Mortality Rate



Hussain, Rumana N ORCID: 0000-0001-8208-5009, Coupland, Sarah E ORCID: 0000-0002-1464-2069, Kalirai, Helen ORCID: 0000-0002-4440-2576, Taktak, Azzam FG, Eleuteri, Antonio ORCID: 0000-0003-0718-6672, Damato, Bertil E, Groenewald, Carl and Heimann, Heinrich
(2021) Small High-Risk Uveal Melanomas Have a Lower Mortality Rate. CANCERS, 13 (9). 2267-.

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Abstract

Our aim was to determine whether size impacts on the difference in metastatic mortality of genetically high-risk (monosomy 3) uveal melanomas (UM). We undertook a retrospective analysis of data from a patient cohort with genetically characterized UM. All patients treated for UM in the Liverpool Ocular Oncology Centre between 2007 and 2014, who had a prognostic genetic tumor analysis. Patients were subdivided into those with small (≤2.5 mm thickness) and large (>2.5 mm thickness) tumors. Survival analyses were performed using Gray rank statistics to calculate absolute probabilities of dying as a result of metastatic UM. The 5-year absolute risk of metastatic mortality of those with small monosomy 3 UM was significantly lower (23%) compared to the larger tumor group (50%) (p = 0.003). Small disomy 3 UM also had a lower absolute risk of metastatic mortality (0.8%) than large disomy 3 UM (6.4%) (p = 0.007). Hazard rates showed similar differences even with lead time bias correction estimates. We therefore conclude that earlier treatment of all small UM, particularly monosomy 3 UM, reduces the risk of metastatic disease and death. Our results would support molecular studies of even small UM, rather than 'watch-and-wait strategies'.

Item Type: Article
Uncontrolled Keywords: uveal melanoma, monosomy 3, metastatic risk
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Clinical Directorate
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Faculty of Science and Engineering > School of Physical Sciences
Depositing User: Symplectic Admin
Date Deposited: 06 Jul 2021 13:13
Last Modified: 18 Jan 2023 21:36
DOI: 10.3390/cancers13092267
Open Access URL: https://www.mdpi.com/2072-6694/13/9/2267
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3129016