Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019

Harvala, Heli, Reynolds, Claire, Ijaz, Samreen, Maddox, Vicki, Penchala, Sujan Dilly, Amara, Alieu ORCID: 0000-0002-1137-2948, Else, Laura, Brailsford, Susan and Khoo, Saye ORCID: 0000-0002-2769-0967 (2022) Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019. SEXUALLY TRANSMITTED INFECTIONS, 98 (2). pp. 132-135.

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Official URL: http://dx.doi.org/10.1136/sextrans-2021-054981

Abstract

<h4>Objective</h4>Due to increased use of pre-exposure prohylaxis (PrEP) and its potential to affect HIV screening of blood donors, we undertook antiretroviral residual testing among HIV-negative male donors in England.<h4>Methods</h4>Residual plasma samples were obtainnd from 46 male donors confirmed positive for syphilis and 96 donors who were repeat reactive for HIV antibodies in screening but confirmed as HIV-negative by reference testing. These were tested for concentrations of tenofovir and emtricitabine by high-performance liquid chromatograhpy coupled with mass spectrometry.<h4>Results</h4>We found evidence of pre-exposure or post-exposure prophylaxis (PrEP/PEP) use in three male blood donors confirmed positive for syphilis (3 out of 46 screened, 6.5%). Two were estimated to have taken PrEP/PEP within a day of donating, and the third within 2 days. Two were new donors, whereas one had donated previously but acquired syphilis infection after his last donation.<h4>Conclusions</h4>Our findings indicate that a small proportion of blood donors have not been disclosing PrEP/PEP use and therefore donating in non-compliance to donor eligibility criteria.

Item Type:	Article
Uncontrolled Keywords:	HIV, pre-exposure prophylaxis, disease transmission, infectious, syphilis
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	07 Jul 2021 10:19
Last Modified:	18 Jan 2023 21:36
DOI:	10.1136/sextrans-2021-054981
Open Access URL:	http://doi.org/10.1136/sextrans-2021-054981
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3129130