Improving anticoagulation in sub-Saharan Africa: What are the challenges and how can we overcome them?

Mouton, JP ORCID: 0000-0002-3511-1259, Blockman, M, Sekaggya-Wiltshire, C, Semakula, J ORCID: 0000-0003-3333-8502, Waitt, C ORCID: 0000-0003-0134-5855, Pirmohamed, M ORCID: 0000-0002-7534-7266 and Cohen, K (2021) Improving anticoagulation in sub-Saharan Africa: What are the challenges and how can we overcome them? British Journal of Clinical Pharmacology, 87 (8). pp. 3056-3068. ISSN 0306-5251, 1365-2125

Access the full-text of this item by clicking on the Open Access link.

Abstract

Patients in sub-Saharan Africa generally have poor anticoagulation control. We review the potential reasons for this poor control, as well as the potential solutions. Challenges include the affordability and centralisation of anticoagulation care, problems with access to medicines and international normalised ratio monitoring, the lack of locally validated standardized dosing protocols, and low levels of anticoagulation knowledge among healthcare workers and patients. Increasing numbers of patients will need anticoagulation in the future because of the increasing burden of noncommunicable disease in the region. We propose that locally developed “warfarin care bundles” which address multiple anticoagulation challenges in combination may be the most appropriate solution in this setting currently.

Item Type:	Article
Uncontrolled Keywords:	anticoagulants, cardiovascular disease, drug utilization, medication safety
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	07 Jul 2021 10:28
Last Modified:	01 Mar 2026 09:56
DOI:	10.1111/bcp.14768
Open Access URL:	https://doi.org/10.1111/bcp.14768
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3129134
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.